Ask any question about EPFL courses, lectures, exercises, research, news, etc. or try the example questions below.
DISCLAIMER: The Graph Chatbot is not programmed to provide explicit or categorical answers to your questions. Rather, it transforms your questions into API requests that are distributed across the various IT services officially administered by EPFL. Its purpose is solely to collect and recommend relevant references to content that you can explore to help you answer your questions.
In order to improve the throughput of the traditional “Two Electrode Voltage Clamp” (TEVC) measurements on Xenopus oocytes, we present here a chip-based non-invasive technique for the measurement of ion channels activity. We focus especially on the integra ...
In the present paper we propose a novel method for the identification and modeling of neural networks using extracellular spike recordings. We create a deterministic model of the effective network, whose dynamic behavior fits experimental data. The network ...
The development of a high-density active microelectrode array for in vitro electrophysiology is reported. Based on the Active Pixel Sensor (APS) concept, the array integrates 4096 gold microelectrodes (electrode separation 20 μm) on a surface of 2.5 mm x 2 ...
An array of electrodes on which cells could be grown directly was fabricated using silicon anisotropic etching and a thick-photoresist process and employed for the detection of nitric oxide (NO) released from a population of adherently growing human umbili ...
Classical experiments on spike timing-dependent plasticity (STDP) use a protocol based on pairs of presynaptic and postsynaptic spikes repeated at a given frequency to induce synaptic potentiation or depression. Therefore, standard STDP models have express ...
Scanning electrochemical microscopy (SECM) was used to characterize addressable microelectrode arrays patterned with 25 regularly spaced (100 μm center to center) 10 μm diameter platinum microdisks. Both the feedback mode and the substrate generation/tip c ...
PhotoMEA is a biosensor useful for the analysis of an in vitro neuronal network, fully based on optical methods. Its function is based on the stimulation of neurons with caged-glutamate and the recording of neuronal activity by fluorescence Voltage-Sensiti ...
In cerebral ischemic preconditioning (IPC), a first sublethal ischemia increases the resistance of neurons to a subsequent severe ischemia. Despite numerous studies, the mechanisms are not yet fully understood. Our goal is to develop an in vitro model of I ...
The study of intracellular communication requires devices that can not only monitor the bioelectric activity, but also control and observe the biochemical environment at the cellular level. This paper reports on the development and characterisation of impl ...
The use of probe beads for lab-on-chip affinity assays is very interesting from a practical point of view. It is easier to handle and trap beads than molecules in microfluidic systems. We present a method for the immobilization of probe beads at defined ar ...
