Concept

Sickle cell disease

Related publications (44)

Retrospectives on Three Decades of Safe Clinical Experience with Allogeneic Dermal Progenitor Fibroblasts: High Versatility in Topical Cytotherapeutic Care

Corinne Scaletta, Philippe Abdel Sayed, Nathalie Hirt-Burri, Alexis Laurent

Allogeneic dermal progenitor fibroblasts constitute cytotherapeutic contenders for modern cutaneous regenerative medicine. Based on advancements in the relevant scientific, technical, and regulatory fields, translational developments have slowly yet steadi ...

MDPI2023

In vitro-transfusional model for red-blood-cell study: the advantage of lowering hematocrit

Gerardo Turcatti, David Crettaz, Michel Prudent, Manon Sandra Bardyn

Background - Thequalityof red blood cells (RBCs) stored in red cell concentrates (RCCs) is influenced by processing, storage and donor characteristics, and can have a clinical impact on transfused patients. To evaluate RBC properties and their potential im ...

Simtipro Srl2023

Novel High-Throughput Fluorescence-Based Assay for the Identification of Nematocidal Compounds That Target the Blood-Feeding Pathway

Gerardo Turcatti, Marc Chambon, Anthony Marchand, Nicola Harris, Tiffany Babette Angélique Bouchery, Mati André Marie Moyat

Hookworm infections cause a neglected tropical disease (NTD) affecting ~740 million people worldwide, principally those living in disadvantaged communities. Infections can cause high morbidity due to their impact on nutrient uptake and their need to feed o ...

2022

Influence of Oxidative Stress on Time-Resolved Oxygen Detection by [Ru(Phen)3]2+ In Vivo and In Vitro

Georges Wagnières, Veronika Huntosova

Detection of tissue and cell oxygenation is of high importance in fundamental biological and in many medical applications, particularly for monitoring dysfunction in the early stages of cancer. Measurements of the luminescence lifetimes of molecular probe ...

2021

Image- and Fluorescence-Based Test Shows Oxidant-Dependent Damages in Red Blood Cells and Enables Screening of Potential Protective Molecules

Gerardo Turcatti, Benjamin Rappaz, David Crettaz, Michel Prudent, Manon Sandra Bardyn

An increase of oxygen saturation within blood bags and metabolic dysregulation occur during storage of red blood cells (RBCs). It leads to the gradual exhaustion of RBC antioxidant protective system and, consequently, to a deleterious state of oxidative s ...

2021

A functional model of adult dentate gyrus neurogenesis

Wulfram Gerstner, Olivia Gozel

In adult dentate gyrus neurogenesis, the link between maturation of newborn neurons and their function, such as behavioral pattern separation, has remained puzzling. By analyzing a theoretical model, we show that the switch from excitation to inhibition of ...

2021

Analysis of the lightning production of convective cells

Marcos Rubinstein, Mohammad Azadifar, Antonio Sunjerga, Amirhossein Mostajabi, Jacopo Grazioli, Nikola Besic, Urs Martin Germann

This paper presents an analysis of the lightningproduction of convective cells. The cells were detected by the MeteoSwiss Thunderstorms Radar Tracking (TRT) algorithm in the course of a lightning measurement campaign thattook place in the summer of 2017 in ...

2019

Systematic reduction of genome-scale models for the study of metabolic phenotypes of human cells

Vassily Hatzimanikatis, Meriç Ataman, Maria Masid Barcon

In the last years, the analysis of cellular metabolism has sparked new interest in systems biology and metabolic modelling. In particular, modelling the phenotypes of healthy and diseased cells will help to understand the main metabolic characteristics of ...

2018

A microfluidics platform for combinatorial drug screening on cancer biopsies

Christoph Merten

Screening drugs on patient biopsies from solid tumours has immense potential, but is challenging due to the small amount of available material. To address this, we present here a plug-based microfluidics platform for functional screening of drug combinatio ...

2018

Miniaturized single-cell analyses for biomedical applications

Loïc Arvind Roger Arm

Numerous diseases affecting living beings have as a cause a modification of gene expression resulting in anomalous expression of proteins in up- or down-regulated fashion, with altered functions or expression of proteins that are not present in the cell in ...

EPFL2017

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