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The ability to control and modulate the action potential firing in neurons represents a powerful tool for neuroscience research and clinical applications. While neuronal excitation has been achieved with many tools, including electrical and optical stimula ...
The ability to construct easily in vitro networks of primary neurons organized with imposed topologies is required for neural tissue engineering as well as for the development of neuronal interfaces with desirable characteristics. However, accumulating evi ...
New technologies launch novel materials; besides their performances in products, their health hazards must be tested. This applies to the lead halide perovskite CH3NH3PbI3 as well, which offers fulgurate applications in photovoltaic devices. We report the ...
Astrocytes can both sense and shape the evolution of neuronal network activity and are known to possess unique ion regulatory mechanisms. Here we explore the relationship between astrocytic intracellular pH dynamics and the synchronous network activity tha ...
— A novel neuron circuit using a Cu/Ti/Al2O3-based conductive-bridge random access memory (CBRAM) device for hardware neural networks that utilize nonvolatile memories as synaptic weights is introduced. The neuronal operations are designed and proved using ...
Institute of Electrical and Electronics Engineers2016
Although several genetic factors have been directly associated to Parkinsonâs disease (PD), no single pathway has emerged to explain the etiology of this neurodegenerative disease. To further understand the cause of Parkinsonâs disease (PD), it is ther ...
The Drosophila larval nervous system is radically restructured during metamorphosis to produce adult specific neural circuits and behaviors. Genesis of new neurons, death of larval neurons and remodeling of those neurons that persistent collectively act to ...
Large multiscale neuronal network simulations are of increasing value as more big data are gathered about brain wiring and organization under the auspices of a current major research initiative, such as Brain Research through Advancing Innovative Neurotech ...
There are currently no disease-modifying therapies for the neurodegenerative disorder Huntington's disease (HD). This study identified novel thiazole-containing inhibitors of the deacetylase sirtuin-2 (SIRT2) with neuroprotective activity in ex vivo brain ...
Epilepsy is characterized by impaired circuit function and a propensity for spontaneous seizures, but how plastic rearrangements within the epileptic focus trigger cortical dysfunction and hyperexcitability is only partly understood. Here we have examined ...