Concept

Diabetes management

Related publications (170)

Combined Optical Coherence and Fluorescence Microscopy to assess dynamics and specificity of pancreatic beta-cell tracers

Theo Lasser, Christophe Pache, Anne Grapin-Botton, Arno Pino Bouwens, Daniel Pawel Szlag, Corinne Berclaz, Antonio Lopez

The identification of a beta-cell tracer is a major quest in diabetes research. However, since MRI, PET and SPECT cannot resolve individual islets, optical techniques are required to assess the specificity of these tracers. We propose to combine Optical Co ...

2015

REST represses a subset of the pancreatic endocrine differentiation program

Anne Grapin-Botton, Yung Hae Kim

To contribute to devise successful beta-cell differentiation strategies for the cure of Type 1 diabetes we sought to uncover barriers that restrict endocrine fate acquisition by studying the role of the transcriptional repressor REST in the developing panc ...

Academic Press Inc Elsevier Science2015

Evidence for a Direct Effect of the NAD(+) Precursor Acipimox on Muscle Mitochondrial Function in Humans

Johan Auwerx, Evan Graehl Williams, Norman Lionel Moullan, Eija Riitta Pirinen

Recent preclinical studies showed the potential of nicotinamide adenine dinucleotide (NAD(+)) precursors to increase oxidative phosphorylation and improve metabolic health, but human data are lacking. We hypothesize that the nicotinic acid derivative acipi ...

American Diabetes Association2015

Bicaudal C1 promotes pancreatic NEUROG3+ endocrine progenitor differentiation and ductal morphogenesis

Daniel Constam, Jacques Rougemont, Anne Grapin-Botton, Joan Goulley, Laurence Anne E Lemaire, Yung Hae Kim

In human, mutations in bicaudal C1 (BICC1), an RNA binding protein, have been identified in patients with kidney dysplasia. Deletion of Bicc1 in mouse leads to left-right asymmetry randomization and renal cysts. Here, we show that BICC1 is also expressed i ...

Company Of Biologists Ltd2015

Morphology, microstructure, crystallography, and chemistry of distinct CaCO3 deposits formed by early recruits of the scleractinian coral Pocillopora damicornis

Anders Meibom, Duncan Thomas Lindsay Alexander, Jaroslaw Hubert Stolarski, Melany Melissa Gilis

ABSTRACT Scleractinian corals begin their biomineralization process shortly after larval settlement with the formation of calcium carbonate (CaCO3) structures at the interface between the larval tissues and the substrate. The newly settled larvae exert var ...

Wiley-Blackwell2015

Morphology, microstructure, crystallography, and chemistry of distinct CaCO3 deposits formed by early recruits of the scleractinian coral Pocillopora damicornis

Anders Meibom, Duncan Thomas Lindsay Alexander, Jaroslaw Hubert Stolarski, Melany Melissa Gilis

Scleractinian corals begin their biomineralization process shortly after larval settlement with the formation of calcium carbonate (CaCO3) structures at the interface between the larval tissues and the substrate. The newly settled larvae exert variable deg ...

Wiley-Blackwell2015

Multilayered genetic and omics dissection of mitochondrial activity in a mouse reference population

Johan Auwerx, Evan Graehl Williams, Adrienne Joëlle Laurence Mottis, Virginija Jovaisaite, Ruedi Aebersold, Sébastien Dubuis

The manner by which genotype and environment affect complex phenotypes is one of the fundamental questions in biology. In this study, we quantified the transcriptome--a subset of the metabolome--and, using targeted proteomics, quantified a subset of the li ...

Cell Press2014

Estimating reliability of blood glucose concentration predictions in patients with type 1 diabetes mellitus

Denis Gillet, Grégory François, Alain Bock

Blood glucose concentrations of patients with type 1 diabetes mellitus are subject to very high inter- and intra-patient variability. This variability may be detrimental to the reliability of the treatment, thus resulting in potentially frequent hypo- or h ...

Elsevier2014

Hepatic glucose sensing and integrative pathways in the liver

Kristina Schoonjans, Maaike Hélène Oosterveer

The hepatic glucose-sensing system is a functional network of enzymes and transcription factors that is critical for the maintenance of energy homeostasis and systemic glycemia. Here we review the recent literature on its components and metabolic actions. ...

Springer Basel Ag2014

TGR5 reduces macrophage migration through mTOR-induced C/EBP beta differential translation

Kristina Schoonjans, Alessia Perino, Matthias Alexander Sokrates Stein, Mitsunori Nomura, Thijs Pols

The bile acid-responsive G protein-coupled receptor TGR5 is involved in several metabolic processes, and recent studies suggest that TGR5 activation may promote pathways that are protective against diet-induced diabetes. Here, we investigated the role of m ...

American Society for Clinical Investigation2014

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