In homological algebra, a branch of mathematics, a quasi-isomorphism or quism is a morphism A → B of chain complexes (respectively, cochain complexes) such that the induced morphisms of homology groups (respectively, of cohomology groups) are isomorphisms for all n. In the theory of , quasi-isomorphisms are sometimes used as the class of weak equivalences when the objects of the category are chain or cochain complexes. This results in a homology-local theory, in the sense of Bousfield localization in homotopy theory.

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