Publications related to Inner mitochondrial membrane

Refining Mitochondria Segmentation in Electron Microscopy Imagery with Active Surfaces

We present an active surface-based method for refining the boundary surfaces of mitochondria segmentation data. We exploit the fact that mitochondria have thick dark membranes, so referencing the image data at the inner membrane can help drive a more accur ...

Springer2014

Endosomes: Guardians Against [Ru(Phen)3]2+ Photo-action In Endothelial Cells During In Vivo pO2 Detection?

Georges Wagnières, Veronika Huntosova

Phototoxicity is a side-effect of in vitro and in vivo oxygen partial pressure (pO(2)) detection by luminescence lifetime measurement methods. Dichlorotris(1,10-phenanthroline)-ruthenium(II) hydrate (Ru(Phen)(3)) is a water soluble pO(2) probe associ ...

Royal Soc Chemistry2014

Hyperpolarized 13C lactate as a substrate for in vivo metabolic studies in skeletal muscle

Rolf Gruetter, Arnaud Comment, Josefina Adriana Maria Bastiaansen, Hikari Ananda Infinity Yoshihara, Yuhei Takado

Resting skeletal muscle has a preference for the oxidation of lipids compared to carbohydrates and a shift towards carbohydrate oxidation is observed with increasing exercise. Lactate is not only an end product in skeletal muscle but also an important meta ...

2014

Functional interaction of Parkinsons disease-associated LRRK2 with members of the dynamin GTPase superfamily

Liliane Glauser, Elpida Tsika, Darren Moore, Klodjan Stafa, Amy Jones, Alessandra Musso

Mutations in LRRK2 cause autosomal dominant Parkinsons disease (PD). LRRK2 encodes a multi-domain protein containing GTPase and kinase domains, and putative proteinprotein interaction domains. Familial PD mutations alter the GTPase and kinase activity of L ...

Oxford University Press2014

Pharmacological Inhibition of Poly(ADP-Ribose) Polymerases Improves Fitness and Mitochondrial Function in Skeletal Muscle

Johan Auwerx, Kristina Schoonjans, Carlos Canto Alvarez, Laurent Mouchiroud, Evan Graehl Williams, Norman Lionel Moullan, Hongbo Zhang, Eija Riitta Pirinen, Keir Joe Menzies, Laia Morato Fornaguera, Wei Li

We previously demonstrated that the deletion of the poly(ADP-ribose) polymerase (Parp)-1 gene in mice enhances oxidative metabolism, thereby protecting against diet-induced obesity. However, the therapeutic use of PARP inhibitors to enhance mitochondrial f ...

Elsevier2014

Cardiolipin Models for Molecular Simulations of Bacterial and Mitochondrial Membranes

Matteo Dal Peraro, Diane Virginie Marie Lançon, Thomas Lemmin, Christophe Bovigny

Present in bacterial and mitochondrial membranes, cardiolipins have a unique dimeric structure, which carries up to two charges (i.e., one per phosphate group) and, under physiological conditions, can be unprotonated or singly protonated. Exhaustive models ...

Amer Chemical Soc2013

Lactate metabolism shift in CHO cell culture: the role of mitochondrial oxidative activity

Florian Maria Wurm, Martin Jordan, Mathieu Benjamin Stettler, Francesca Zagari

Lactate production is monitored in industrial processes as a crucial metabolite for cultured mammalian cells. Typically lactate is strongly produced during the exponential growth phase, while its net consumption is frequently observed when cells enter into ...

Elsevier2013

Piezoresistive Membrane-Type Surface Stress Sensor Arranged In Arrays For Cancer Diagnosis Through Breath Analysis

Nico de Rooij, Terunobu Akiyama, Sebastian Gautsch, Peter Vettiger, Frédéric Loizeau, Christoph Gerber

We present the fabrication, characterization and successful medical application of a membrane-type surface stress sensor (MSS), arranged in arrays for molecular detection in gaseous phase. Made out of SOI substrate, a round membrane with a diameter of 5 0 ...

IEEE2013

In vivo detection of brain Krebs cycle intermediate by hyperpolarized magnetic resonance

Rolf Gruetter, Mor-Miri Mishkovsky, Arnaud Comment

The Krebs (or tricarboxylic acid (TCA)) cycle has a central role in the regulation of brain energy regulation and metabolism, yet brain TCA cycle intermediates have never been directly detected in vivo. This study reports the first direct in vivo observati ...

Nature Publishing Group2012

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Inner mitochondrial membrane

Refining Mitochondria Segmentation in Electron Microscopy Imagery with Active Surfaces

Endosomes: Guardians Against [Ru(Phen)3]2+ Photo-action In Endothelial Cells During In Vivo pO2 Detection?

Hyperpolarized 13C lactate as a substrate for in vivo metabolic studies in skeletal muscle

Functional interaction of Parkinsons disease-associated LRRK2 with members of the dynamin GTPase superfamily

Pharmacological Inhibition of Poly(ADP-Ribose) Polymerases Improves Fitness and Mitochondrial Function in Skeletal Muscle

Cardiolipin Models for Molecular Simulations of Bacterial and Mitochondrial Membranes

Lactate metabolism shift in CHO cell culture: the role of mitochondrial oxidative activity

Piezoresistive Membrane-Type Surface Stress Sensor Arranged In Arrays For Cancer Diagnosis Through Breath Analysis

Multidisciplinary Analysis of the Metabolic Shift to Lactate Consumption in CHO Cell Culture

In vivo detection of brain Krebs cycle intermediate by hyperpolarized magnetic resonance

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Endosomes: Guardians Against [Ru(Phen)3]2+ Photo-action In Endothelial Cells During In Vivo pO2 Detection?

Piezoresistive Membrane-Type Surface Stress Sensor Arranged In Arrays For Cancer Diagnosis Through Breath Analysis

Hyperpolarized 13C lactate as a substrate for in vivo metabolic studies in skeletal muscle

Functional interaction of Parkinsons disease-associated LRRK2 with members of the dynamin GTPase superfamily

Pharmacological Inhibition of Poly(ADP-Ribose) Polymerases Improves Fitness and Mitochondrial Function in Skeletal Muscle

Cardiolipin Models for Molecular Simulations of Bacterial and Mitochondrial Membranes

Lactate metabolism shift in CHO cell culture: the role of mitochondrial oxidative activity

Multidisciplinary Analysis of the Metabolic Shift to Lactate Consumption in CHO Cell Culture

In vivo detection of brain Krebs cycle intermediate by hyperpolarized magnetic resonance

Refining Mitochondria Segmentation in Electron Microscopy Imagery with Active Surfaces