Concept

Inner mitochondrial membrane

Related publications (76)

Targeting Sirtuin 1 to Improve Metabolism: All You Need Is NAD(+)?

Sirtuin 1 (SIRT1) is an evolutionarily conserved NAD(+)-dependent deacetylase that is at the pinnacle of metabolic control, all the way from yeast to humans. SIRT1 senses changes in intracellular NAD(+) levels, which reflect energy level, and uses this inf ...

2012

Membrane-Type Surface Stress Sensor with Piezoresistive Readout

Nico de Rooij, Terunobu Akiyama, Sebastian Gautsch, Peter Vettiger, Frédéric Loizeau

We present the fabrication and characterization of a membrane-type surface stress sensor (MSS), arranged in arrays for molecular detection in gaseous phase. Made out of SOI substrate, a round membrane with a diameter of 500 mu m and a thickness of 2.5 mu m ...

Elsevier Science Bv2012

Glutamate transport decreases mitochondrial pH and modulates oxidative metabolism in astrocytes

Hélène Danielle Perreten Lambert, Sylvain Eric Lengacher, Jean-Yves Chatton

During synaptic activity, the clearance of neuronally released glutamate leads to an intracellular sodium concentration increase in astrocytes that is associated with significant metabolic cost. The proximity of mitochondria at glutamate uptake sites in as ...

2011

Lentiviral Transgenesis as a Tool to Study the Role of Uncoupling Protein Isoforms in the Nervous System

Hélène Danielle Perreten Lambert

A tight coupling exists between synaptic activity and glucose utilization by astrocytes. Metabolic cooperation between neurons and astrocytes mediates this coupling. During synaptic activation, glutamate that is released in the synaptic cleft as a neurotra ...

EPFL2011

Cardiac and Skeletal Muscle Defects in a Mouse Model of Human Barth Syndrome

Richardus Houtkooper

Barth syndrome is an X-linked genetic disorder caused by mutations in the tafazzin (taz) gene and characterized by dilated cardiomyopathy, exercise intolerance, chronic fatigue, delayed growth, and neutropenia. Tafazzin is a mitochondrial transacylase requ ...

2011

Cytotoxic Property of Surfactant-Cobalt(III) Complexes on a Human Breast Cancer Cell Line

The cancer chemotherapeutic potential of surfactant-cobalt(III) complexes, cis-Co(bpy)(2)(C14H29NH2)Cl(2) center dot 3 H2O (1) and cis-Co(phen)(2)(C14H29NH2)Cl(2) center dot 3 H2O (2) (bpy 2,2 '-bipyridine, phen 1,10-phenanthroline) on MCF- ...

2011

Coassembly of Mgm1 isoforms requires cardiolipin and mediates mitochondrial inner membrane fusion

Henning Paul-Julius Stahlberg

Two dynamin-related protein (DRP) families are essential for fusion of the outer and inner mitochondrial membranes, Fzo1 (yeast)/Mfn1/Mfn2 (mammals) and Mgm1 (yeast)/Opa1 (mammals), respectively. Fzo1/Mfns possess two medial transmembrane domains, which pl ...

Rockefeller University Press2009

Mitochondrial bovine ADP/ATP carrier in detergent is predominantly monomeric but also forms multimeric species

ADP/ATP carriers (AACs) are major and essential constituents of the inner mitochondrial membrane. They drive the import of ADP and the export of newly synthesized ATP. They were described as functional dimers from the 1980s until the structures of the AAC ...

American Chemical Society2008

Mini review on the structure and supramolecular assembly of VDAC

The Voltage Dependent Anion Channel (VDAC) is the most abundant protein in the outer membrane of mitochondria. This strategic localization puts it at the heart of a great number of phenomena. Its recent implication in apoptosis is an example of the major i ...

2008

Bridging across length scales: Multi-scale ordering of supported lipid bilayers via lipoprotein self-assembly and surface patterning

Henning Paul-Julius Stahlberg

We show that a two-step process, involving spontaneous self-assembly of lipids and apolipoproteins and surface patterning, produces single, supported lipid bilayers over two discrete and independently adjustable length scales. Specifically, an aqueous phas ...

American Chemical Society (ACS)2008

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