Concept

Development of the cerebral cortex

Related publications (59)

MicroRNA-124 Is a Subventricular Zone Neuronal Fate Determinant

Didier Trono, Isabelle Barde, Sonia Verp, Johan Jakobsson

New neurons are continuously generated from neural stem cells with astrocyte properties, which reside in close proximity to the ventricle in the postnatal and adult brain. In this study we found that microRNA-124 (miR-124) dictates postnatal neurogenesis i ...

Society for Neuroscience2012

Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex

Johannes Gräff

How neurons develop their morphology is an important question in neurobiology. Here we describe a new pathway that specifically affects the formation of basal dendrites and axonal projections in cortical pyramidal neurons. We report that thousand-and-one-a ...

2012

Synergistic NGF/B27 Gradients Position Synapses Heterogeneously in 3D Micropatterned Neural Cultures

Philippe Renaud, Dominique Zosso, Ana Valero, Anja Kunze

Native functional brain circuits show different numbers of synapses (synaptic densities) in the cerebral cortex. Until now, different synaptic densities could not be studied in vitro using current cell culture methods for primary neurons. Herein, we presen ...

Public Library of Science2011

Fluoxetine regulates the expression of neurotrophic/growth factors and glucose metabolism in astrocytes

Pierre Magistretti, Jean-Luc Martin, Igor Allaman

RATIONALE: The pharmacological actions of most antidepressants are ascribed to the modulation of serotonergic and/or noradrenergic transmission in the brain. During therapeutic treatment for major depression, fluoxetine, one of the most commonly prescribed ...

Springer Verlag2011

Altered branching patterns of Purkinje cells in mouse model for cortical development disorder

Giorgio Margaritondo

Disrupted cortical cytoarchitecture in cerebellum is a typical pathology in reeler. Particularly interesting are structural problems at the cellular level: dendritic morphology has important functional implication in signal processing. Here we describe a c ...

2011

Prematurity and prenatal growth restriction differently affects brain connectivity at age 6 years.

Jean-Philippe Thiran, Elda Fischi Gomez, Reto Meuli, Patric Hagmann, Djalel Eddine Meskaldji, Leila Cammoun, François Lazeyras

Survival of children born prematurely or with very low birth weight has increased dramatically but the long term developmental outcome remains a concern with many children having deficits in their cognitive capacities, in particular involving executive dom ...

2010

A Sox1 to Pax6 switch drives neuroectoderm to radial glia progression during differentiation of mouse embryonic stem cells

David Michael Suter

The transcription factors Sox1 and Pax6 are expressed sequentially during early mouse embryonic neurogenesis. Sox1 expression starts upon formation of neuroectoderm, whereas Pax6 is subsequently expressed in radial glial cells, the latter giving rise to mo ...

2009

Microfluidic hydrogel layers with multiple gradients to stimulate and perfuse three-dimensional neuronal cell cultures

Philippe Renaud, Arnaud Bertsch, Michele Giugliano, Anja Kunze

We present a simple and easy to handle PDMS microfluidic device for neuronal cell culture studies in three-dimensional hydrogel scaffolds. The hydrogel is structured in parallel layers to reconstruct cell layers close to the natural environment. Dissociate ...

Elsevier2009

Global brain connectivity analysis by diffusion MR tractography

Xavier Gigandet

The human cerebral cortex consists of approximately 1010 neurons that are organized into a complex network of local circuits and long-range connections. During the past years there has been an increasing interest from the neuro-scientific community towards ...

EPFL2009

Evolution amplified processing with temporally dispersed slow neuronal connectivity in primates

Hassan Ghaziri, Giorgio Innocenti

The corpus callosum (CC) provides the main route of communication between the 2 hemispheres of the brain. In monkeys, chimpanzees, and humans, callosal axons of distinct size interconnect functionally different cortical areas. Thinner axons in the genu and ...

National Academy of Sciences2009

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