The somatic nervous system (SNS), or voluntary nervous system is the part of the peripheral nervous system associated with the voluntary control of body movements via skeletal muscles.
The somatic nervous system consists of nerves carrying afferent nerve fibers, which relay sensation from the body to the central nervous system (CNS), and nerves carrying efferent nerve fibers, which relay motor commands from the CNS to stimulate muscle contraction.
The a- of afferent and the e- of efferent correspond to the prefixes ad- (to, toward) and ex- (out of).
There are 43 segments of nerves in the human body. With each segment, there is a pair of sensory and motor nerves. In the body, 31 segments of nerves are in the spinal cord and 12 are in the brain stem. Besides these, thousands of association nerves are also present in the body.
Thus the somatic nervous system consists of two parts:
Spinal nerves: They are mixed nerves that carry sensory information into and motor commands out of the spinal cord.
Cranial nerves: They are the nerve fibers that carry information into and out of the brain stem. They include smell, eye muscles, mouth, taste, ear, neck, shoulders, and tongue.
The somatic nervous system controls all voluntary muscular systems within the body, and the process of voluntary reflex arcs.
The basic route of nerve signals within the efferent somatic nervous system involves a sequence that begins in the upper cell bodies of motor neurons (upper motor neurons) within the precentral gyrus (which approximates the primary motor cortex). Stimuli from the precentral gyrus are transmitted from upper motor neurons, down the corticospinal tract, to lower motor neurons (alpha motor neurons) in the brainstem and ventral horn of the spinal cord: upper motor neurons release a neurotransmitter called glutamate from their axon terminal knobs, which is received by glutamate receptors on the lower motor neurons: from there, acetylcholine is released from the axon terminal knobs of alpha motor neurons and received by postsynaptic receptors (nicotinic acetylcholine receptors) of muscles, thereby relaying the stimulus to contract muscle fibers.
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The human brain is the central organ of the human nervous system, and with the spinal cord makes up the central nervous system. The brain consists of the cerebrum, the brainstem and the cerebellum. It controls most of the activities of the body, processing, integrating, and coordinating the information it receives from the sense organs, and making decisions as to the instructions sent to the rest of the body. The brain is contained in, and protected by, the skull bones of the head.
Muscle contraction is the activation of tension-generating sites within muscle cells. In physiology, muscle contraction does not necessarily mean muscle shortening because muscle tension can be produced without changes in muscle length, such as when holding something heavy in the same position. The termination of muscle contraction is followed by muscle relaxation, which is a return of the muscle fibers to their low tension-generating state.
Afferent nerve fibers are axons (nerve fibers) of sensory neurons that carry sensory information from sensory receptors to the central nervous system. Many afferent projections arrive at a particular brain region. In the peripheral nervous system afferent nerve fibers are part of the sensory nervous system and arise from outside of the central nervous system. Sensory and mixed nerves contain afferent fibers.
The aim of this course is two-fold:
i) to describe the molecular properties of some important drug targets
ii) to illustrate some applications of drugs active at the nervous system
The goal of the course is to guide students through the essential aspects of molecular neuroscience and neurodegenerative diseases. The student will gain the ability to dissect the molecular basis of
This course will provide the fundamental knowledge in neuroscience required to
understand how the brain is organised and how function at multiple scales is
integrated to give rise to cognition and beh
This course will provide the fundamental knowledge in neuroscience required to
understand how the brain is organised and how function at multiple scales is
integrated to give rise to cognition and beh
This course will provide the fundamental knowledge in neuroscience required to
understand how the brain is organised and how function at multiple scales is
integrated to give rise to cognition and beh
Explores brain circuits for sensory perception and external representation, covering thalamus communication, energy-saving mechanisms, inhibitory control, and time perception.
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EPFL2024
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