Concept

Tumour heterogeneity

Related publications (116)

Development and Characterization of a Microfluidic Chip to Capture Circulating Prostate Cancer Cells

The analysis of circulating tumor cells (CTCs) from the blood of cancer patients promises a better understanding of metastasis formation and tumor phenotypes. CTCs are rare (there is 1 CTC in 1 billion of circulating blood cells) and therefore challenging ...

2011

Novel organometallic ruthenium complexes for selective activation in tumour cells

Anna Katherine Renfrew

In recent years, ruthenium-based antitumour drugs have emerged as an attractive alternative to cisplatin, exhibiting both excellent activity in tumours where cisplatin is of limited use and low general toxicity, leading to reduced side effects. Two rutheni ...

EPFL2010

Studies toward new anti-cancer strategies based on alpha-mannosidase inhibition

Sandrine Gerber

Changes in the glycosylation pattern of cellular glycoproteins constitute a hallmark in human cancer and influence tumour progression, suggesting that inhibitors of selected glycosidases may control cancer invasion. Following the studies on swainsonine, a ...

Schweizerische Chemische Gesellschaft2010

Selective Breast Cancer Cell Capture, Culture, and Immunocytochemical Analysis Using Self-Assembled Magnetic Bead Patterns in a Microfluidic Chip

Martinus Gijs, Jean-Claude Bünzli, Caroline Vandevyver, Venkataragavalu Sivagnanam, Bo Song

Separation and subsequent culturing of MCF-7 breast cancer cells on self-assembled protein-coated magnetic beads in a microfluidic chip is demonstrated. The beads were patterned in situ inside a sealed microfluidic channel using magnetic-field-assisted ele ...

American Chemical Society2010

Requirement for NF-kappaB signalling in a mouse model of lung adenocarcinoma

Etienne Meylan

NF-kappaB transcription factors function as crucial regulators of inflammatory and immune responses as well as of cell survival. They have also been implicated in cellular transformation and tumorigenesis. However, despite extensive biochemical characteriz ...

2009

Learning approach to analyze tumour heterogeneity in DCE-MRI data during anti-cancer treatment

Alessandro Daducci

The paper proposes a learning approach to support medical researchers in the context of in-vivo cancer imaging, and specifically in the analysis of Dynamic Contrast-Enhanced MRI (DCE-MRI) data. Tumour heterogeneity is characterized by identifying regions w ...

2009

Inhibition of tyrosine kinase receptors by SU6668 promotes abnormal stromal development at the periphery of carcinomas

Alessandro Daducci

Dynamic contrast-enhanced (albumin-Gd-DTPA) magnetic resonance imaging, performed during 2 weeks of daily administration of an inhibitor of tyrosine kinase receptors (SU6668) in an HT-29 colon carcinoma model, revealed the onset of a hyper-enhancing rim, n ...

Nature Publishing Group2009

Search for new anti-cancer heterocyclic compounds

Claudia Bello

Tumors consist of cells whose growth and morphological characteristics are markedly different from those of normal cells. Observation of human and animal models argue that tumor development proceeds via a process formally analogous to Darwinian evolution, ...

EPFL2009

A stroma-related gene signature predicts resistance to neoadjuvant chemotherapy in breast cancer

Michel Aguet, Mauro Delorenzi, Pascale Anderle Pedone, Sylvie André Baflast

To better understand the relationship between tumor-host interactions and the efficacy of chemotherapy, we have developed an analytical approach to quantify several biological processes observed in gene expression data sets. We tested the approach on tumor ...

Nature Publishing Group2009

DNA delivery by microinjection for the generation of recombinant mammalian cell lines

Florian Maria Wurm, David Hacker, Madiha Derouazi, Sébastien Chenuet

Gene transfer methods for producing recombinant cell lines are often not very efficient. One reason is that the recombinant DNA is delivered into the cell cytoplasm and only a small fraction reaches the nucleus. This chapter describes a method for microinj ...

Humana Press2009

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