Concept

Clostridioides difficile infection

Related publications (57)

From natural product to marketed drug: the tiacumicin odyssey

The first members of the tiacumicin family of antibiotics, encompassing more than 40 compounds, were isolated in 1975. Structurally, the core aglycon is an 18-membered macrolactone having two conjugated diene units, one isolated double bond, 5 stereogenic ...

Royal Soc Chemistry2013

Gut-associated microbes of Drosophila melanogaster

Bruno Lemaitre, Nichole Broderick

There is growing interest in using Drosophila melanogaster to elucidate mechanisms that underlie the complex relationships between a host and its microbiota. In addition to the many genetic resources and tools Drosophila provides, its associated microbiota ...

2012

Seasonal variations of antibiotics measured in the environment from sales data analysis

Luca Rossi, Sylvain Coutu, Jonas Margot, Christa McArdell

Antibiotics are substances commonly consumed by the population under medical prescriptions. These compounds may reach the environment through human excretion as they are partially eliminated in WWTPs. The occurrence of antibiotics in the aquatic environmen ...

2011

TGR5 Activation Inhibits Atherosclerosis by Reducing Macrophage Inflammation and Lipid Loading

Johan Auwerx, Kristina Schoonjans, Mitsunori Nomura, Thijs Pols, Taoufiq Harach, Maaike Hélène Oosterveer, Giuseppe Lo Sasso

The G protein-coupled receptor TGR5 has been identified as an important component of the bile acid signaling network, and its activation has been linked to enhanced energy expenditure and improved glycemic control. Here, we demonstrate that activation of T ...

Elsevier2011

Flow-through immunomagnetic separation system for waterborne pathogen isolation and detection: Application to Giardia and Cryptosporidium cell isolation

Qasem Alramadan

Simultaneous sample washing and concentration of two waterborne pathogen samples were demonstrated using a rotational magnetic system under continuous flow conditions. The rotation of periodically arranged small permanent magnets close to a fluidic channel ...

Elsevier2010

Photodynamic therapy as a novel therapeutic approach for the treatment of Crohn's disease

Hubert van den Bergh, Georges Wagnières, Dominique Velin

Photodynamic therapy (PDT) may modify the mucosal immune response and thus serve as a therapy for Crohn’s disease (CD). After evaluating safety in BALB/c mice and establishing an endoscopic index of colitis (EIC), we could demonstrate that a single «low do ...

2006

Two proteases defining a melanization cascade in the immune system of Drosophila

Bruno Lemaitre

The melanization reaction is used as an immune mechanism in arthropods to encapsulate and kill microbial pathogens. In Drosophila, the serpin Spn27A regulates melanization apparently by inhibiting the protease that activates phenoloxidase, the key enzyme i ...

American Society for Biochemistry and Molecular Biology2006

Drosophila host defense after oral infection by an entomopathogenic Pseudomonas species

Bruno Lemaitre

Drosophila has been shown to be a valuable model for the investigation of host-pathogen interactions. Study of the Drosophila immune response has been hampered, however, by the lack of true Drosophila pathogens. In nearly all studies reported, the bacteria ...

National Academy of Sciences2005

Bacterial subversion of lipid rafts

Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami

Bacteria rely on numerous basic cellular functions of their target cells to reach successful infection. The recent discovery that the plasma membrane contains specialized microdomains, called lipid rafts, with many specific functions but in particular with ...

Elsevier2004

Effects of tylosin on bacterial mucolysis, Clostridium perfringens colonization, and intestinal barrier function in a chick model of necrotic enteritis

Bart Deplancke

Necrotic enteritis (NE) is a worldwide poultry disease caused by the alpha toxin-producing bacterium Clostridium perfringens. Disease risk factors include concurrent coccidial infection and the dietary use of cereal grains high in nonstarch polysaccharides ...

2003

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