The concept of self-replicating spacecraft, as envisioned by mathematician John von Neumann, has been described by futurists including physicist Michio Kaku and discussed across a wide breadth of hard science fiction novels and stories. Self-replicating probes are sometimes referred to as von Neumann probes. Self-replicating spacecraft would in some ways either mimic or echo the features of living organisms or viruses. Von Neumann proved that the most effective way of performing large-scale mining operations such as mining an entire moon or asteroid belt would be by self-replicating spacecraft, taking advantage of their exponential growth. In theory, a self-replicating spacecraft could be sent to a neighbouring planetary system, where it would seek out raw materials (extracted from asteroids, moons, gas giants, etc.) to create replicas of itself. These replicas would then be sent out to other planetary systems. The original "parent" probe could then pursue its primary purpose within the star system. This mission varies widely depending on the variant of self-replicating starship proposed. Given this pattern, and its similarity to the reproduction patterns of bacteria, it has been pointed out that von Neumann machines might be considered a form of life. In his short story "Lungfish" (see Self-replicating machines in fiction), David Brin touches on this idea, pointing out that self-replicating machines launched by different species might actually compete with one another (in a Darwinistic fashion) for raw material, or even have conflicting missions. Given enough variety of "species" they might even form a type of ecology, or – should they also have a form of artificial intelligence – a society. They may even mutate with untold thousands of "generations". The first quantitative engineering analysis of such a spacecraft was published in 1980 by Robert Freitas, in which the non-replicating Project Daedalus design was modified to include all subsystems necessary for self-replication.

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