Concept

Broad-spectrum antibiotic

Related publications (78)

Novel Chemosensors for Biologically Important Analytes

In this work, fluorescent-based chemosensors for the detection of important analytes in aqueous solution are described. The sensors are based on different detection concepts, including analyte-induced aggregation/de-aggregation, pattern-based sensing and m ...

EPFL2015

Photosensitizing and Inhibitory Effects of Ozonated Dissolved Organic Matter on Triplet-Induced Contaminant Transformation

Urs von Gunten, Silvio Canonica

Dissolved organic matter (DOM) is both a promoter and an inhibitor of triplet-induced organic contaminant oxidation. This dual role was systematically investigated through photochemical experiments with three types of DOM of terrestrial and aquatic origins ...

American Chemical Society2015

Pattern-based sensing of aminoglycosides with fluorescent amphiphiles

Rosario Scopelliti, Kay Severin

A mixture of two amphiphiles with fluorescent head groups can be used as a sensing ensemble for the pattern-based analysis of aminoglycoside antibiotics. In buffered aqueous solution, the amphiphiles form a dynamic mixture of micellar aggregates. In the pr ...

Royal Soc Chemistry2014

Dielectrophoresis-based purification of antibiotic-treated bacterial subpopulations

Philippe Renaud, John McKinney, Neeraj Dhar, Rodrigo Martinez Duarte, Meltem Elitas

Persistence of bacteria during antibiotic therapy is a widespread phenomenon, of particular importance in refractory mycobacterial infections such as leprosy and tuberculosis. Persistence is characterized by the phenotypic tolerance of a subpopulation of b ...

Royal Soc Chemistry2014

Anticytolytic Screen Identifies Inhibitors of Mycobacterial Virulence Protein Secretion

Stewart Cole, Claudia Sala, Ruben Hartkoorn, Andrej Benjak, Anthony Vocat, Ming Zhang, Jan Lars Rybniker, Jeffrey Chen, Edina Rita Székely

Mycobacterium tuberculosis (Mtb) requires protein secretion systems like ESX-1 for intracellular survival and virulence. The major virulence determinant and ESX-1 substrate, EsxA, arrests phagosome maturation and lyses cell membranes, resulting in tissue d ...

Cell Press2014

Targeting Bacterial Central Metabolism for Drug Development

John McKinney, Paul Murima

Current antibiotics, derived mainly from natural sources, inhibit a narrow spectrum of cellular processes, namely DNA replication, protein synthesis, and cell wall biosynthesis. With the worldwide explosion of drug resistance, there is renewed interest in ...

Elsevier2014

Sunlight-induced transformation of sulfadiazine and sulfamethoxazole in surface waters and wastewater effluents

Urs von Gunten, Silvio Canonica

Sulfadiazine (SD) and sulfamethoxazole (SMX) are widely used sulfonamide antibiotics, which are present as contaminants in surface waters and are known to undergo phototransformation. This kinetic study was conducted to identify the processes responsible f ...

Elsevier2014

From natural product to marketed drug: the tiacumicin odyssey

Jieping Zhu

The first members of the tiacumicin family of antibiotics, encompassing more than 40 compounds, were isolated in 1975. Structurally, the core aglycon is an 18-membered macrolactone having two conjugated diene units, one isolated double bond, 5 stereogenic ...

Royal Soc Chemistry2013

Pattern-Based Sensing of Peptides and Aminoglycosides with a Single Molecular Probe

Rosario Scopelliti, Kay Severin, Christian Heinis, Shiyu Chen, Bo Ram Lee

A coumarin-based molecular probe can be used for the sensing of peptides and aminoglycoside antibiotics. The probe reacts with the primary amine group(s) of the analytes to give a mixture of covalent adducts with distinct colors. Each analyte gives rise to ...

American Chemical Society2013

Antibiotic-induced modifications of the stiffness of bacterial membranes

Giovanni Dietler, Sandor Kasas, Giovanni Longo, Laura Rio Marques

In the latest years the importance of high resolution analysis of the microbial cell surface has been increasingly recognized. Indeed, in order to better understand bacterial physiology and achieve rapid diagnostic and treatment techniques, a thorough inve ...

Elsevier2013

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