Concept

Segmentation (biology)

Related publications (85)

Opening a can of centipedes: New insights into mechanisms of body segmentation

The search for a common developmental genetic mechanism of body segmentation appears to become more difficult, and more interesting, as new segmented organisms are added to the roster. Recent work in this journal by Brena and Akam on segmentation of the ge ...

2013

A switch between topological domains underlies HoxD genes collinearity in mouse limbs

Didier Trono, Denis Duboule, Marion Leleu, Daniël Noordermeer, Guillaume Andrey

Hox genes are major determinants of the animal body plan, where they organize structures along both the trunk and appendicular axes. During mouse limb development, Hoxd genes are transcribed in two waves: early on, when the arm and forearm are specified, a ...

Amer Assoc Advancement Science2013

Duplications of hox gene clusters and the emergence of vertebrates

Denis Duboule

The vertebrate body plan is characterized by an increased complexity relative to that of all other chordates and large-scale gene amplifications have been associated with key morphological innovations leading to their remarkable evolutionary success. Here, ...

Academic Press Inc Elsevier Science2013

Angular Momentum During Unexpected Multidirectional Perturbations Delivered While Walking

Silvestro Micera

This study investigated the hypothesis that the coupled contribution of all body segments to the whole-body response during both walking and managing unexpected perturbations is characterized by similar features which do not depend on the laterality (i.e., ...

Ieee-Inst Electrical Electronics Engineers Inc2013

Anatomically plausible illusory posture affects mental rotation of body parts

Olaf Blanke, Silvio Ionta, Anna Sforza, Mariko Funato

During mental rotation (MR) of body parts, people internally simulate the movement of their corresponding body segments. These sensory-motor mechanisms render MR sensitive to proprioceptive information (e.g., posture). Similar mechanisms can alter illusory ...

Springer2013

Chromatin organization and global regulation of Hox gene clusters

Denis Duboule

During development, a properly coordinated expression of Hox genes, within their different genomic clusters is critical for patterning the body plans of many animals with a bilateral symmetry. The fascinating correspondence between the topological organiza ...

Royal Soc2013

Patterning embryos with oscillations: Structure, function and dynamics of the vertebrate segmentation clock

Andrew Charles Oates

The segmentation clock is an oscillating genetic network thought to govern the rhythmic and sequential subdivision of the elongating body axis of the vertebrate embryo into somites: the precursors of the segmented vertebral column. Understanding how the rh ...

2012

Breathe in and straighten your back: Hypoxia, notch, and scoliosis

Andrew Charles Oates

In this issue of Cell, Sparrow et al. propose a new mechanism for sporadically occurring congenital scoliosis in which Notch signaling and hypoxia converge in the embryo on somite patterning via the segmentation clock. This interaction between hypoxia and ...

2012

Topology and Dynamics of the Zebrafish Segmentation Clock Core Circuit

Bart Deplancke, Andrew Charles Oates, Sebastian Maerkl, Daniele Soroldoni, Alina Isakova

During vertebrate embryogenesis, the rhythmic and sequential segmentation of the body axis is regulated by an oscillating genetic network termed the segmentation clock. We describe a new dynamic model for the core pace-making circuit of the zebrafish segme ...

Public Library Science2012

Topology and dynamics of the zebrafish segmentation clock core circuit

Bart Deplancke, Andrew Charles Oates, Sebastian Maerkl, Daniele Soroldoni, Alina Isakova

2012

Graph Chatbot

Chat with Graph Search

Ask any question about EPFL courses, lectures, exercises, research, news, etc. or try the example questions below.

DISCLAIMER: The Graph Chatbot is not programmed to provide explicit or categorical answers to your questions. Rather, it transforms your questions into API requests that are distributed across the various IT services officially administered by EPFL. Its purpose is solely to collect and recommend relevant references to content that you can explore to help you answer your questions.