Protein Induced Degradation: Druggability Strategy
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Explores the selection and rationale of preclinical animal models in drug development, emphasizing the 10 to 15-year path to a marketed small-molecule drug.
Explores proteinopathy mapping, connecting proteotoxicity to intrinsic functions of aggregation-prone proteins, with a focus on alpha-synuclein and Parkinson's Disease.
Explores quantitative proteome profiling for drug target identification through activity-based protein profiling and advanced mass spectrometry techniques.
Explores membrane protein quality control mechanisms at the ER, focusing on ERAD recognition, retrotranslocation, ubiquitination, and degradation of misfolded proteins.
