Mitochondrial Hsp70: Import and Protein Folding

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Early Events in the Heat Shock Response: Action in the Nucleus

Explores early events in the Heat Shock Response, focusing on Hsf1 regulation, Hsp70 dynamics, and the role of Sis1.

Single Molecule Studies: Hsp90 Chaperone

Explores single-molecule studies of the Hsp90 chaperone and protein function using optical tweezers.

Post-translational regulation of ER proteostasis

Explores the post-translational regulation of ER proteostasis, focusing on BiP chaperone activity, ER stress response, and FICD-mediated AMPylation.

Cell Energy Production: Metabolic Signaling

Explores cell energy production, metabolic signaling pathways, and the coordination between TCA cycle and OXPHOS.

Proteinopathy Mapping: Connecting Proteotoxicity to Intrinsic Functions

Explores proteinopathy mapping, connecting proteotoxicity to intrinsic functions of aggregation-prone proteins, with a focus on alpha-synuclein and Parkinson's Disease.

Glycolysis and Krebs Cycle

Explains glycolysis, fermentation, Krebs cycle, ATP production, and electron transport chain in mitochondria.

Protein Folding: Navigating Energy Landscapes

Explores protein folding, chaperone assistance, entropy impact, and non-equilibrium states in protein stabilization.

Electron Transport Chain: Proton Pumps and Coenzyme Q

Explores the Electron Transport Chain in mitochondria, focusing on proton pumps and Coenzyme Q.

Computational Protein Design

Series explores computational protein design, covering challenges, applications, and importance in bioengineering and synthetic biology.

Protein Homeostasis: Golgi Apparatus Mechanisms

Explores protein homeostasis mechanisms at the Golgi apparatus, including quality control, proteotoxic stress impact, and induced protein unfolding.