Lecture

Thermodynamics in Metabolic Pathways

In course

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Description

This lecture explores the application of thermodynamics in metabolic pathways, focusing on the use of Flux Balance Analysis and the formulation of the problem as a Mixed Integer Linear Programming. It discusses the constraints imposed by thermodynamics, the role of bi-directional reactions, and the group contribution method for estimating Gibbs free energy. The uncertainty in linear regression models and the impact of experimental errors are also covered. Additionally, it delves into the influence of factors like pH and ionic strength on free energy calculations, as well as the effect of crowding conditions on metabolic pathway feasibility.

Instructor

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Official source

https://mediaspace.epfl.ch/media/0_9j4m3zvi

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Ontological neighbourhood

Statistics

Statistical inference: Sensitivity analysis

Data analysis: Regression analysis

Physics

Thermodynamics: Statistical mechanics

Biology

Cell biology: Metabolism

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