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Flux Balance Analysis: Optimization and Phenotypic Phase Planes
This lecture covers the principles of Flux Balance Analysis (FBA) and its application in optimizing metabolic networks. It discusses the constraints and objective functions used in FBA to find optimal solutions. Additionally, it explores Phenotypic Phase Planes, illustrating the relationship between growth rate and nutrient uptake rates. The lecture also delves into Flux Variability Analysis and alternative flux profiles, showcasing different solutions for maximizing growth. Furthermore, it touches on gene essentiality studies and bioenergetics, explaining the thermodynamics and metabolic pathways involved in cellular energy production.