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Metal-Ligand Dual Activation
This lecture covers the concept of metal-ligand dual activation, focusing on cyanide addition and Noyori hydrogenation. It discusses the mechanisms and applications of bifunctional catalysts in asymmetric reactions, such as cyanohydrin synthesis and transfer hydrogenation of ketones. The lecture also explores the role of chiral acids and metals in enamine chemistry, radical reactions, and the addition of metal alkyl reagents. Various catalysts, mechanisms, and selectivity models are presented, highlighting the importance of anion binding, H-bonding, and chiral ligands in organic synthesis.