Catalytic Asymmetric Reactions in Organic Synthesis

This lecture covers the principles and mechanisms of catalytic asymmetric reactions in organic synthesis, focusing on topics such as HOMO activation, enamine catalysis, phase-transfer catalysis, chiral ylides generation, and dual activation strategies. The instructor discusses key concepts like chiral enolate generation, enamine catalysis mechanisms, and the superiority of silylated prolinol. Various examples and mechanisms are presented, including the formation of chiral ylides, enantioselective nucleophilic substitutions, and atroposelective bromination. The lecture also explores the use of phosphorane bases, iminocyclopropenes, and vinylogous pinacol rearrangements in asymmetric synthesis.