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This lecture covers the regulation of the cell cycle, focusing on the control of Cyclin-Dependent Kinases (CDKs) and Cyclins. It explains how CDKs are activated by Cyclins, the role of phosphorylation in regulating CDK activity, and the mechanisms of CDK inhibition. The lecture also discusses the importance of checkpoints in the cell cycle, which prevent cell division if certain conditions are not met. Various examples of checkpoints are provided, highlighting their role in ensuring the fidelity of cell cycle events.