Molecular Mechanism of Hsp70 Chaperones: Interactions with Cochaperones and Substrates

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Protein Disaggregation by Hsp70 Chaperone System

Explores protein disaggregation by the Hsp70 chaperone system and the significance of aggregate modification for protein refolding.

Chaperone Mechanism of Grp94: Elucidating ER Protein Quality Control

Explores the chaperone mechanism of Grp94 in ER protein quality control and client protein activation.

Cellular Heat Shock Response: Rethinking the Significance

Delves into the cellular heat shock response, emphasizing the absence of a sensor mechanism and the restoration of misfolded protein aggregates.

Hsp70 Mechanism: Unfolding & Entropic Pulling

Explores Hsp70's role in protein unfolding and entropic pulling, discussing chaperone-driven stabilization and ATP hydrolysis.

Hsp70 Molecular Chaperones: Conformational Flexibility and Function

Explores the conformational and functional flexibility of Hsp70 molecular chaperones, focusing on folding intermediates and the Hsp70 functional cycle.

Chaperone-Mediated Disaggregation: Amyloid Fibrils and Hsp70

Explores chaperone-mediated disaggregation of amyloid fibrils by Hsp70 in neurodegenerative diseases.

Protein-Repair Machineries: Evolution and Function

Explores the evolution and function of protein-repair machineries, emphasizing the role of ATP-fueled unfolding machines in preventing protein aggregation and promoting proper folding.

Early Events in the Heat Shock Response: Action in the Nucleus

Explores early events in the Heat Shock Response, focusing on Hsf1 regulation, Hsp70 dynamics, and the role of Sis1.

Biomolecular Condensation: Hsf1 in Stress Response

Delves into Hsf1's role in stress response through dynamic transcriptional condensate formation during heat shock.

J-Domain Protein Specificity: Genetics Insights

Explores the genetic basis of J-domain protein specificity and the essential role of Sis1 in protein homeostasis.