Chaperone Mechanism of Grp94: Elucidating ER Protein Quality Control

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Explores the molecular mechanism and client preference of chaperonin GroEL in protein folding and aggregation prevention.

Hsp70 Chaperone Binding: Substrate Selectivity and Function

Explores the selective promiscuity in binding of the E. coli Hsp70 chaperone to unfolded or misfolded protein substrates, examining its implications in protein folding mechanisms.

Protein Co-evolution Analysis

Delves into protein co-evolution analysis, covering discoveries, residue contacts, and direct coupling analysis.

Post-translational regulation of ER proteostasis

Explores the post-translational regulation of ER proteostasis, focusing on BiP chaperone activity, ER stress response, and FICD-mediated AMPylation.

Hsp70 Interaction with Measles Virus Nucleoprotein

Explores the interaction between hsp70 and the intrinsically disordered Ntail domain of the measles virus nucleoprotein.

J-Domain Protein Specificity: Genetics Insights

Explores the genetic basis of J-domain protein specificity and the essential role of Sis1 in protein homeostasis.

Protein Dynamics: ClpB Machinery and Single-Molecule FRET Studies

Explores protein dynamics, focusing on ClpB machinery, fast conformational changes, and substrate translocation mechanisms.

The Molecular Interactions that Shape Tau Polymorphs

Explores the molecular interactions shaping tau polymorphs and the role of Hsp40s in regulating tau aggregation.

Computational Protein Design: Principles and Challenges

Covers the principles and challenges of computational protein design in bioengineering.

Non-refoldability in E. coli Proteome

Delves into non-refoldability in the E. coli proteome, exploring protein folding challenges and implications.