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This lecture by the instructor delves into the B-physics anomalies observed in recent data, focusing on Lepton Flavor Universality violations in semi-leptonic decays of the b quark. The anomalies are analyzed through a general Effective Field Theory (EFT) approach, leading to model-building considerations. The lecture explores the implications of the anomalies, the need for EFT Lagrangian, and the importance of FCNC and four-quark operators. The discussion also covers the LFU ratios, the role of Leptoquarks in generating effective operators, and the multi-scale picture involving flavor symmetries. The instructor concludes by highlighting the significance of the anomalies and the potential for new non-standard effects to emerge.