Catalytic Asymmetric Reactions in Organic Chemistry

This lecture covers the principles and applications of catalytic asymmetric reactions in organic chemistry, focusing on topics such as HOMO activation, enamine catalysis, and multi-bond forming processes. It also discusses the use of silylated prolinols and binaphthyl catalysts, as well as guanidinium and cinchona alkaloid-based strategies for phase transfer catalysis. The lecture delves into the mechanisms of various reactions, including the Aldol and Mannich reactions, and explores the use of proline derivatives and binaphthyl scaffolds in catalysis. Additionally, it examines the reversed approach of iminium activation with carboxylate for cyclopropanation and the combination of enamine and ion pair activation. The lecture concludes with a discussion on squaramide and dieneamines in metal-ligand dual activation.