Frontiers in Chemical Biology

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Drug Discovery: Computational Approaches

Explores the EXSCALATE4COV project, focusing on computational drug discovery for COVID-19 treatments and the collaboration between academia and industry.

DNA-Encoded Libraries

Explores DNA-encoded libraries for drug discovery, covering synthesis techniques, pros and cons, and diverse DEL methods.

Drug Target Discovery: Thermal Shift Profiling

Covers drug target discovery through stability shifts and proteomics with isobaric tags.

Kidney-on-a-Chip Technologies

Covers the state-of-the-art kidney-on-chip technologies aiming to facilitate pharmaceutical research and eliminate animal testing.

Protein Mass Spectrometry and Proteomics: Techniques and Applications

Explores protein mass spectrometry techniques, including labeling methods, quantitation, and biomarker discovery.

Fragment-Based Drug Discovery: Concepts & Technologies

Covers the concepts and technologies of fragment-based drug discovery, hit identification methods, and its application in target-based drug discovery.

Synthetic Biology: Therapeutic Advancement

Introduces synthetic biology for disease treatment, covering RNA therapeutics, drug discovery, and gene circuits.

Protein Modifications: Ubiquitination and Acylation

Explores protein modifications through ubiquitination, acylation, and Ras acylation importance.

Preclinical Animal Models: Selection & Rationale

Explores the selection and rationale behind preclinical animal models in drug discovery, emphasizing understanding mechanisms of action and domain specificity.

Chemical Biology: High-Throughput and High-Content Screening

Covers Chemical Biology, high-throughput screening, RNA interference, CRISPR-Cas9, and organoid differentiation for drug discovery.