DNA Repair Mechanisms

This lecture covers mutations, including single base pair substitutions, deletions, insertions, and major chromosomal alterations. It explains the classification of mutations based on molecular change, phenotypic impact, location, and mode of acquisition. The lecture also discusses spontaneous mutations, replication errors, tautomers, and DNA base damage. Furthermore, it delves into induced mutations caused by mutagens like base analogs, alkylating agents, intercalating agents, adduct-forming agents, UV light, ionizing radiation, and free radicals. The DNA repair systems, such as proofreading, mismatch repair, chemical reversal, excision repair, and double-stranded break repair, are also explored.