Catalytic Cycloadditions: Enantioselective Strategies

This lecture covers various catalytic cycloadditions, focusing on enantioselective strategies such as Ni-catalyzed [3+3] cycloaddition of nitrones, dynamic kinetic asymmetric transformation with donor-acceptor cyclopropanes, and the first desymmetrization approach. It also discusses the use of chiral ketones and guanidinium catalysts for the Claisen rearrangement, as well as the activation of electrophiles other than carbonyl/imines. The lecture delves into the mechanisms, catalyst designs, and computational models behind these reactions, providing insights into the electronic influences on selectivity and the development of asymmetric reactions.