Person
Lilia Noriega Lopez
This person is no longer with EPFL
Related publications (8)
SIRT7 modulates the stability and activity of the renal K-Cl cotransporter KCC4 through deacetylation
Johan Auwerx, Dongryeol Ryu, Olivier Staub, Lilia Noriega Lopez
SIRT7 is a NAD(+)-dependent deacetylase that controls important aspects of metabolism, cancer, and bone formation. However, the molecular targets and functions of SIRT7 in the kidney are currently unknown. In silico analysis of kidney transcripts of the BX ...
2021Genistein increases the thermogenic program of subcutaneous WAT and increases energy expenditure in mice
Lilia Noriega Lopez, Laura Alejandra Velazquez Villegas
White adipose tissue (WAT) can differentiate into beige adipose tissue by the browning process. Some polyphenols, including isoflavones, particularly genistein, are suggested to increase the expression of browning markers. There is evidence that consumptio ...
ELSEVIER SCIENCE INC2019Metabolic Characterization of a Sirt5 deficient mouse model
Johan Auwerx, Kristina Schoonjans, Norman Lionel Moullan, Lilia Noriega Lopez, Jiujiu Yu
Sirt5, localized in the mitochondria, is a member of sirtuin family of NAD(+)-dependent deacetylases. Sirt5 was shown to deacetylate and activate carbamoyl phosphate synthase 1. Most recently, Sirt5 was reported to be the predominant protein desuccinylase ...
Nature Publishing Group2013The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation
Johan Auwerx, Kristina Schoonjans, Lilia Noriega Lopez, Mitsunori Nomura, Thijs Pols
Bile acids (BAs) are amphipathic molecules that facilitate the uptake of lipids, and their levels fluctuate in the intestine as well as in the blood circulation depending on food intake. Besides their role in dietary lipid absorption, bile acids function a ...
Elsevier2011The bile acid membrane receptor TGR5: a valuable metabolic target
Johan Auwerx, Kristina Schoonjans, Lilia Noriega Lopez, Mitsunori Nomura, Thijs Pols
Bile acids (BAs) are amphipathic molecules that facilitate the uptake of lipids, and their levels fluctuate in the intestines as well as in the circulation depending on food intake. Besides their role in dietary lipid absorption, BAs function as signaling ...
2011CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability
Johan Auwerx, Carlos Canto Alvarez, Chikage Mataki, Hiroyasu Yamamoto, Lilia Noriega Lopez, Jiujiu Yu
The nicotinamide adenine dinucleotide (NAD(+))-dependent deacetylase SIRT1 is a major metabolic regulator activated by energy stresses such as fasting or calorie restriction. SIRT1 activation during fasting not only relies on the increase in the NAD(+)/NAD ...
2011AMPK regulates energy expenditure by modulating NAD(+) metabolism and SIRT1 activity
Johan Auwerx, Carlos Canto Alvarez, Lilia Noriega Lopez
AMP-activated protein kinase (AMPK) is a metabolic fuel gauge conserved along the evolutionary scale in eukaryotes that senses changes in the intracellular AMP/ATP ratio. Recent evidence indicated an important role for AMPK in the therapeutic benefits of m ...
2009TGR5-mediated bile acid sensing controls glucose homeostasis
Johan Auwerx, Kristina Schoonjans, Chikage Mataki, Hiroyasu Yamamoto, Lilia Noriega Lopez
TGR5 is a G protein-coupled receptor expressed in brown adipose tissue and muscle, where its activation by bile acids triggers an increase in energy expenditure and attenuates diet-induced obesity. Using a combination of pharmacological and genetic gain- a ...
2009