Publications by Taoufiq Harach

Administrations of human adult ischemia-tolerant mesenchymal stem cells and factors reduce amyloid beta pathology in a mouse model of Alzheimer's disease

Theo Lasser, Tristan Bolmont, Taoufiq Harach, Fabien Louis Claude Robert Jammes, Nicolas Jean Marc Antoine Duthilleul, Valentin Laurent Herbert Zufferey

The impact of human adult ischemia-tolerant mesenchymal stem cells (hMSCs) and factors (stem cell factors) on cerebral amyloid beta (Aβ) pathology was investigated in a mouse model of Alzheimer's disease (AD). To this end, hMSCs were administered intraveno ...

Elsevier2017

Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota

Theo Lasser, Tristan Bolmont, Taoufiq Harach, Nicolas Jean Marc Antoine Duthilleul

Alzheimer’s disease is the most common form of dementia in the western world, however there is no cure available for this devastating neurodegenerative disorder. Despite clinical and experimental evidence implicating the intestinal microbiota in a number o ...

2017

Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly

Tristan Bolmont, Taoufiq Harach

The pathway leading from amyloid-b deposition to cognitive impairment is believed to be a cornerstone of the pathogenesis of Alzheimer's disease (AD). However, what drives amyloid buildup in sporadic nongenetic cases of AD is still unknown. AD brains featu ...

Elsevier Science Inc2017

Gastro-intestinal biomarkers for diagnosis and therapies of proteinopathies

Theo Lasser, Tristan Bolmont, Taoufiq Harach

Pharmaceutical composition for the treatment of proteinopathies comprising products which are able to stimulate growth or inhibition of at least one of Odoribacter, Oscillospira, Dehalobacterium, Alistipes, Parabacteroides, Lactobacillus and Sutterella, Fi ...

2016

Use of waste products for detecting amyloidogenic proteinaceous material in living mammals

Theo Lasser, Patrick Fraering, Tristan Bolmont, Taoufiq Harach

Method for detecting amyloidogenic proteinaceous material induced by a proteopathy, for instance Alzheimer's disease, characterized by the fact that said amyloidogenic proteinaceous material is detected in a mammal waste product, such as feces. ...

2013

Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis

Johan Auwerx, Kristina Schoonjans, Carlos Canto Alvarez, Pénélope Andreux, Norman Lionel Moullan, Eija Riitta Pirinen, Hiroyasu Yamamoto, Taoufiq Harach, Pablo Jose Fernandez Marcos, Ellen Helena Jeninga

Sirt3 is a mitochondrial sirtuin, predominantly expressed in highly metabolic tissues. Germline ablation of Sirt3 has major metabolic consequences, including increased susceptibility to metabolic damage and oxidative stress after high fat feeding. In order ...

2012

LRH-1-dependent glucose sensing determines intermediary metabolism in liver

Johan Auwerx, Kristina Schoonjans, Norman Lionel Moullan, Chikage Mataki, Hiroyasu Yamamoto, Taoufiq Harach, Maaike Hélène Oosterveer

Liver receptor homolog 1 (LRH-1), an established regulator of cholesterol and bile acid homeostasis, has recently emerged as a potential drug target for liver disease. Although LRH-1 activation may protect the liver against diet-induced steatosis and insul ...

American Society for Clinical Investigation2012

TGR5 potentiates GLP-1 secretion in response to anionic exchange resins

Johan Auwerx, Kristina Schoonjans, Mitsunori Nomura, Thijs Pols, Taoufiq Harach, Adriano Maida

Anionic exchange resins are bona fide cholesterol-lowering agents with glycemia lowering actions in diabetic patients. Potentiation of intestinal GLP-1 secretion has been proposed to contribute to the glycemia lowering effect of these non-systemic drugs. H ...

2012

TGR5 Activation Inhibits Atherosclerosis by Reducing Macrophage Inflammation and Lipid Loading

Johan Auwerx, Kristina Schoonjans, Mitsunori Nomura, Thijs Pols, Taoufiq Harach, Maaike Hélène Oosterveer, Giuseppe Lo Sasso

The G protein-coupled receptor TGR5 has been identified as an important component of the bile acid signaling network, and its activation has been linked to enhanced energy expenditure and improved glycemic control. Here, we demonstrate that activation of T ...

Elsevier2011

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