Cross coupling of non-activated alkyl halides is a potentially transformative methodology in organic synthesis. Herein we review the recent development of nickel-catalyzed coupling of non-activated alkyl halides. The current understanding of the mechanism of these coupling reactions is highlighted. As the mechanism is ligand-dependant, the perspective is organized according to the types of ligands employed in the catalysis.
Jean-Philippe Ansermet, Marcin Bialek
Auke Ijspeert, Jonathan Patrick Arreguit O'Neill, Simon Lukas Hauser, Matthieu Guillaume Marie Dujany
Michael Graetzel, Dan Ren, Yelin Hu, Jun Li, Reza Zamani, Xiaoyan Wang, Ziyun Wang, Yi Xu