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Global and stage specific patterns of krüppel-associated-box zinc finger protein gene expression in murine early embryonic cells

Related publications (60)

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Unraveling the KRAB/KAP1 control of transposable elements in pluripotent and somatic cells

Gabriela Ecco

Transposable elements (TEs) are DNA sequences able to change position in the genome, and represent more than 40% of mammalian genetic material. TEs can have positive or detrimental effects on the host, being both important motors of evolution and genomic t ...

EPFL2016

Stem cell niche engineering through photopatterning and microfluidics

Laura Kolb

The application of stem cells in drug screening and regenerative therapy has led to important advances in basic biology and biomedicine. Such strategies require high cell numbers and the efficient maturation into faithful functional organ or tissue units. ...

EPFL2016

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Mitotic bookmarking transcription factors remain bound to chromosomes during mitosis and were proposed to regulate phenotypic maintenance of stem and progenitor cells at the mitosis-to-G1 (M-G1) transition. However, mitotic bookmarking remains largely unex ...

Cold Spring Harbor Laboratory2016

Cell-Imprinted Substrates Modulate Differentiation, Redifferentiation, and Transdifferentiation

Philippe Renaud, Arnaud Bertsch, Omid Mashinchian, Mojtaba Taghipoor, Morteza Mahmoudi, Shahin Bonakdar, Leila Montazeri

Differentiation of stem cells into mature cells through the use of physical approaches is of great interest. Here, we prepared smart nanoenvironments by cell-imprinted substrates based on chondrocytes, tenocytes, and semifibroblasts as templates and demons ...

Amer Chemical Soc2016

Transposable elements (TEs) may account for up to two-thirds of the human genome, and as genomic threats they are subjected to epigenetic control mechanisms engaged from the earliest stages of embryonic development. We previously determined that an importa ...

2016

TAF4 (TATA-binding protein-associated factor 4) and its paralogue TAF4b are components of the TFIID core module. We inactivated the murine Taf4a gene to address Taf4 function during embryogenesis. Here we show that Taf4a(-/-) embryos survive until E9.5 whe ...

Nature Publishing Group2016

Non-integrating episomal plasmid-based reprogramming of human amniotic fluid stem cells into induced pluripotent stem cells in chemically defined conditions

Lilia Salimova

Amniotic fluid stem cells (AFSC) represent an attractive potential cell source for fetal and pediatric cell-based therapies. However, upgrading them to pluripotency confers refractoriness toward senescence, higher proliferation rate and unlimited different ...

Taylor & Francis Inc2016

Defined three-dimensional microenvironments boost induction of pluripotency

Matthias Lütolf, Alessandra Piersigilli, Adrian Ranga, Yoji Tabata, Yuya Okawa, Massimiliano Caiazzo

Since the discovery of induced pluripotent stem cells (iPSCs), numerous approaches have been explored to improve the original protocol, which is based on a two-dimensional (2D) cell-culture system. Surprisingly, nothing is known about the effect of a more ...

Nature Publishing Group2016

Traceless Synthesis of Asymmetrically Modified Bivalent Nucleosomes

Beat Fierz, Carolin Christine Lechner, Ninad Dilip Agashe

Nucleosomes carry extensive post-translational modifications (PTMs), which results in complex modification patterns that are involved in epigenetic signaling. Although two copies of each histone coexist in a nucleosome, they may not carry the same PTMs and ...

Wiley-V C H Verlag Gmbh2016

The Developmental Control of Transposable Elements and the Evolution of Higher Species

Didier Trono, Marc Samuel Friedli

Transposable elements (TEs) account for at least 50% of the human genome. They constitute essential motors of evolution through their ability to modify genomic architecture, mutate genes and regulate gene expression. Accordingly, TEs are subject to tight e ...

Annual Reviews2015