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Prototype Foamy Virus Bet Impairs the Dimerization and Cytosolic Solubility of Human APOBEC3G

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The 70 kDa heat shock protein (Hsp70) chaperones control protein homeostasis in all ATP-containing cellular compartments. J-domain proteins (JDPs) coevolved with Hsp70s to trigger ATP hydrolysis and catalytically upload various substrate polypeptides in ne ...

Elsevier Science Inc2024

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The ongoing war in Ukraine has profoundly impacted the Ukrainian scientific community. Numerous researchers have either emigrated or transitioned to alternate professions. For those who remain in research, the destruction of civil infrastructure and psycho ...

London2023

Deconstructing body axis morphogenesis in zebrafish embryos using robot-assisted tissue micromanipulation

Andrew Charles Oates, Mahmut Selman Sakar, Ece Özelçi, Erik Mailand, Matthias Rüegg

Classic microsurgical techniques, such as those used in the early 1900s by Mangold and Spemann, have been instrumental in advancing our understanding of embryonic development. However, these techniques are highly specialized, leading to issues of inter-ope ...

2022

SIRT7 modulates the stability and activity of the renal K-Cl cotransporter KCC4 through deacetylation

Johan Auwerx, Dongryeol Ryu, Olivier Staub, Lilia Noriega Lopez

SIRT7 is a NAD(+)-dependent deacetylase that controls important aspects of metabolism, cancer, and bone formation. However, the molecular targets and functions of SIRT7 in the kidney are currently unknown. In silico analysis of kidney transcripts of the BX ...

2021

Reproducibility warning: The curious case of polyethylene glycol 6000 and spheroid cell culture

Francesco Stellacci, Quy Ong Khac, Ahmet Bekdemir, Zhi Luo

Reproducibility of results is essential for a well-designed and conducted experiment. Several reasons may originate failure in reproducing data, such as selective reporting, low statistical power, or poor analysis. In this study, we used PEG6000 samples fr ...

2020

DELF: Safeguarding deletion correctness in Online Social Networks

Georgios Damaskinos

Deletion is a core facet of Online Social Networks (OSNs). For users, deletion is a tool to remove what they have shared and control their data. For OSNs, robust deletion is both an obligation to their users and a risk when developer mistakes inevitably oc ...

USENIX ASSOC2020

We confirm, for the primes up to 3000, the conjecture of Bourgain-Gamburd-Sarnak and Baragar on strong approximation for the Markoff surface modulo primes. For primes congruent to 3 modulo 4, we find data suggesting that some natural graphs constructed fro ...

TAYLOR & FRANCIS INC2020

Benchmarking Touchscreen Biometrics for Mobile Authentication

We study user interaction with touchscreens based on swipe gestures for personal authentication. This approach has been analyzed only recently in the last few years in a series of disconnected and limited works. We summarize those recent efforts and then c ...

2018

Several lineages of symbiotic bacteria in insects selfishly manipulate host reproduction to spread in a population 1 , often by distorting host sex ratios. Spiroplasma poulsonii2,3 is a helical and motile, Gram-positive symbiotic bacterium that resides in ...

2018

Parkin mediates the ubiquitination of VPS35 and modulates retromer-dependent endosomal sorting

Liliane Glauser, Elpida Tsika, Darren Moore

Mutations in a number of genes cause familial forms of Parkinson's disease (PD), including mutations in the vacuolar protein sorting 35 ortholog (VPS35) and parkin genes. In this study, we identify a novel functional interaction between parkin and VPS35. W ...

OXFORD UNIV PRESS2018