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Off-axis digital holographic camera for quantitative phase microscopy

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Phase imaging is widely used in biomedical imaging, sensing, and material characterization, among other fields. However, direct imaging of phase objects with subwavelength resolution remains a challenge. Here, we demonstrate subwavelength imaging of phase ...

Springernature2024

High sensitivity, incoherent differential imaging

Chiara Bonati

Microscopic visualisation of optically transparent samples has been a topic of interest for several decades. Features such as density or chemical composition can influence the optical phase of transmitted light, and phase contrast can reveal these structur ...

EPFL2022

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We introduce a lock-in method to increase the phase contrast in incoherent Differential Phase Contrast (DPC) imaging. The use of a smart pixel detector with in-pixel signal demodulation, paired with synchronized illumination, provides the basis of a bit-ef ...

SPIE-INT SOC OPTICAL ENGINEERING2022

Lock-in incoherent differential phase contrast imaging

Christophe Moser, Timothé Laforest, Damien Claude-Marie Loterie, Chiara Bonati

We introduce a lock-in method to increase the phase contrast in incoherent differential phase contrast (DPC) imaging. This method improves the phase sensitivity by the analog removal of the background. The use of a smart pixel detector with in-pixel signal ...

CHINESE LASER PRESS2022

Label-free, scalable and point-of-care imaging platform for rapid analysis of biomarker

Hatice Altug, Filiz Yesilköy, Alexander Belushkin, Yasaman Jahani

We propose a disruptive point-of-care (PoC) imaging platform based on lens-free interference phase-contrast imaging for rapid detection of biomarker such as for sepsis and potentially other diseases (e.g. cancer). It enables simultaneous analysis of potent ...

SPIE-INT SOC OPTICAL ENGINEERING2019

Compact lensless digital holography

Manon Rostykus

Microscopy is of high interest for biology since it allows imaging features that are too small to be seen with naked eyes. However, cells are mostly transparent to visible and infrared light which makes it difficult to see with a traditional microscope. To ...

EPFL2018

Coherent imaging from bacteria to multicellular organisms

Séverine Coquoz

Structural and functional imaging of cells, tissues and organisms is crucial for understanding biomedical processes. Fluorescence microscopy is an established tool and has contributed to many discoveries in the life sciences. This technique provides molecu ...

EPFL2017

Compact Side and Multi Angle Illumination Lensless Imager and Method of Operating the Same

Christophe Moser, Manon Rostykus

A system for subpixel resolution imaging of an amplitude and quantitative phase image, the system including a waveguide having a top plane, a bottom plane, and two sides, an array of light sources emitting first befit beams from one side of the two sides o ...

2017

Quantitative phase-digital holographic microscopy: a new imaging modality to identify original cellular biomarkers of diseases

Pierre Magistretti, Christian Depeursinge, Benjamin Rappaz, Pierre Marquet, Pascal Jourdain, Kaspar Rothenfusser

Quantitative phase microscopy (QPM) has recently emerged as a powerful label-free technique in the field of living cell imaging allowing to non-invasively measure with a nanometric axial sensitivity cell structure and dynamics. Since the phase retardation ...

Spie-Int Soc Optical Engineering2016

Compressed imaging by sparse random convolution

Theo Lasser, Aurélien Bourquard, Antonio Lopez

The theory of compressed sensing (CS) shows that signals can be acquired at sub-Nyquist rates if they are sufficiently sparse or compressible. Since many images bear this property, several acquisition models have been proposed for optical CS. An interestin ...

Optical Society of America2016