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A Monolithic biosensing platform is presented for miniaturized amperometric electrochemical sensing in CMOS. The system consists of a fully-integrated current readout circuit for differential current measurement as well as on-die sensors developed by growing Platinum nano-structures (Pt-nanoS) on top of electrodes implemented with the top metal layer. The circuit is based on the switch-capacitor technique and includes pseudo-differential integrators for concurrent sampling of the differential sensor currents. The circuit further includes a differential to single converter and a programmable gain amplifier prior to an ADC. The system is fabricated in 0.35 μm technology and measures current within ±20 μA with minimum input-referred noise of 0.47 pA and consumes 9.3 mW from a 3.3 V supply. Differential sensing for nano-structured sensors is proposed to build highly-sensitive and offset-free sensors for metabolite detection. This is successfully tested for bio-nano-sensors for the measurement of glucose in sub-mili Molar concentrations with the proposed readout IC. The on-die electrodes are nanos- tructured and cyclic voltammetry run successfully through the readout IC to demonstrate detection of H2O2.
Elison de Nazareth Matioli, Remco Franciscus Peter van Erp, Palliyage Srilak Nirmana Perera, Georgios Kampitsis
Edoardo Charbon, Andrei Ardelean, Emanuele Ripiccini, Andrada Alexandra Muntean, Esteban Venialgo Araujo