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Cryogenic Vibrational Spectroscopy Provides Unique Fingerprints for Glycan Identification

Related publications (60)

Synthesis of C-linked Disaccharides and Analogues as Biomimetics of the TF Epitope

Glycoproteins and glycolipids are major components of the outer surface of mammalian cells. Their carbohydrate moieties, which are directed into the outer environment, serve as ligands for receptor proteins, such as lectins, pathogen proteins and antibodie ...

EPFL2011

Transduction of Glycan-Lectin Binding Using Near-Infrared Fluorescent Single-Walled Carbon Nanotubes for Glycan Profiling

Ardemis Anoush Boghossian

There is significant interest in developing new detection platforms for characterizing glycosylated proteins, despite the lack of easily synthesized model glycans or high affinity receptors for this anal. problem. In this work, the authors demonstrate a se ...

2011

Preparation and characterization of Poly(Ethylene Glycol)/gamma-CD Polyrotaxanes using beta-CD derivatives as a capping reagent

Blaise Tardy

As living systems understanding got better, as life could be modeled in a batch, using immortalized cells, researches in fundamental sciences found startling applications of advanced techniques on living systems. As the biomaterial field developed various ...

2009

A Low-Noise Single-Photon Detector Implemented in a 130 nm CMOS Imaging Process

Edoardo Charbon, Cristiano Niclass, Marek Gersbach

We report on a new single-photon avalanche diode (SPAD) fabricated in a 130 nm CMOS imaging process. A novel circular structure combining shallow trench isolation (STI) and a passivation implant creates an effective guard ring against premature edge breakd ...

2009

Chemical and isotopic analysis of hydrocarbon gas at trace levels. Methodology and results

Jérôme Chappellaz

This chapter discusses the work carried out to establish the link between climate and atmospheric composition over the last million years, a period over which archives from different media offer precious information with a high degree of detail and accurac ...

Elsevier2009

Anomeric effects in pyranosides and related acetals

Pierre Vogel, Sandrine Gerber

The anomeric effect, originally defined as the preference of an electronegative substituent at the anomeric position of pyranosides to stand in an axial rather than an equatorial position, results from the combination of multiple steric, stereoelectronic a ...

RCS Publishing2009

High Resolution Mass Spectrometry for Studying the Interactions of Cisplatin with Oligonucleotides

Paul Joseph Dyson, Yury Tsybin, Christian Hartinger, Hisham Ben Hamidane

Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) has been used to probe the interaction of the anticancer drug cisplatin with oligonucleotides. The binding kinetics, the nature of the adducts formed, and the location of the binding s ...

2008

Capillary electrophoresis hyphenated to inductively coupled plasma-mass spectrometry: A novel approach for the analysis of anticancer metallodrugs in human serum and plasma

Christian Hartinger, Michael Groessl

The development of metal-based chemotherapeutics lacks methods which are capable of providing early indication on the potential of new metal complexes as future anticancer drugs. Since most of these compounds are administered intravenously, serum proteins ...

2008

Recent Synthetic Approaches Toward Non-anomeric Spiroketals in Natural Products

Pierre Vogel, Sandrine Gerber, Sylvain Favre

Many natural products of biological interest contain [6,5]- and [6,6]-spiroketal moieties that can adopt various configurations, benefiting or not from anomeric conformation stabilizing effects. The spiroketal fragments are often important for the biologic ...

2008

Integrated calorimetric microreactor in low-temperature cofired ceramic (LTCC) technology

Peter Ryser, Thomas Maeder, Yannick Sébastien Fournier, Raphael Willigens

Object of this work 1) Explore the feasibility of an LTCC microreactor • Chemical stability: compatible with HCl, NaOH, ... • Thermal stability to >100°C 2) Achieve a high degree of integration • Temperature measurement • Reactant flow measurement • Temper ...

2006

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