Publications related to Platinum(II) Complexes with O,S Bidentate Ligands: Biophysical Characterization, Antiproliferative Activity, and Crystallographic Evidence of Protein Binding

Photoactive sawhorse-type diruthenium tetracarbonyl complexes

Sawhorse-type diruthenium tetracarbonyl complexes incorporating carboxyphenyl porphyrin bridges and pyridine axial ligands have been prepared, characterized and evaluated as potential photosensitizing and chemotherapeutic agents in several human cancer cel ...

Elsevier2012

Encapsulation of hydrophobic pyrenyl-cycloplatinate complexes within a water-soluble arene ruthenium metalla-cage

Olivier Pierre Zava

Two hydrophobic pyrenyl-containing cycloplatinate complexes (2-(1-pyrenyl)pyridine)Pt(acac) (Pt-1) and {2-(4-(1-pyrenyl)phenyl)pyridine}Pt(acac) (Pt-2) (acac = acetylacetonato) have been encapsulated in the hexacationic water-soluble metalla-cage [(p-cymen ...

2012

Highly cytotoxic trithiophenolatodiruthenium complexes of the type [(eta(6)-p-MeC6H4Pr (i) )(2)Ru-2(SC6H4-p-X)(3)](+): synthesis, molecular structure, electrochemistry, cytotoxicity, and glutathione oxidation potential

Paul Joseph Dyson, Olivier Pierre Zava, Mathurin Baquié

A series of cationic dinuclear p-cymene ruthenium trithiophenolato complexes of the type (eta(6)-p-MeC6H4Pr (i) )(2)Ru-2(SC6H4-p-X)(3) (1 X is H, 2 X is Me, 3 X is Ph, 4 X is Br, 5 X is OH, 6 X is NO2, 7 X is OMe, 8 X is CF3, 9 X is F, 10 X is Pr (i) ...

2012

Enhancement of irradiation effects on cancer cells by cross-linked dextran-coated iron oxide (CLIO) nanoparticles

Giorgio Margaritondo

We investigated iron oxide nanoparticles with two different surface modifications, dextran coating and cross-linked dextran coating, showing that their different internalization affects their capability to enhance radiation damage to cancer cells. The inte ...

Institute of Physics2010

Functional analysis and knock‐down phenotype of BCL9 and BCL9L in cancer cell lines

Fanny Bringolf

Therapy‐resistant tumor cells often display EMT and stem cell‐like traits. The canonical Wnt pathway has been associated with these phenotypes in many cancer types. Our group has shown in mice that two proteins of this pathway, Bcl9 and Bcl9l, participate ...

2010

Highly Cytotoxic Copper(II) Complexes with Modified Paullone Ligands

Paul Joseph Dyson, Olivier Pierre Zava

The reaction of copper(II) chloride or copper(II) acetate with 6-N-(2-N',N'-dimethylaminoethylamino)-7,12-dihydroindolo-[3,2-d][1]benzazepine (HL1), 9-bromo-6-N-(2-N',N'-dimethylaminoethylamino)-7,12-dihydroindolo[3,2-d][1]benzazepine (HL2), N-9-bromo-7,12 ...

2010

Maltol-Derived Ruthenium-Cymene Complexes with Tumor Inhibiting Properties: The Impact of Ligand-Metal Bond Stability on Anticancer Activity In Vitro

Christian Hartinger, Alexey Nazarov

Organometallic rutheniumarene compounds bearing a maltol ligand have been shown to be nearly inactive in in vitro anticancer assays, presumably due to the formation of dimeric Ru-II species in aqueous solutions. In an attempt to stabilize such complexes, [ ...

2009

A Novel Cytotoxic Cerium Complex: Aquatrichloridobis(1,10-phenanthroline)cerium(III) (KP776). Synthesis, Characterization, Behavior in H2O, Binding towards Biomolecules, and Antiproliferative Activity

Michael Groessl

The lanthanide complex aquatrichloridobis(1,10-phenanthroline)cerium(III) [Ce(phen)(2)(H2O)Cl-3] (KP776) was fully characterized by elemental analysis, IR-, and H-1- and C-13-NMR spectroscopy, as well as TG/DTA measurements, and its behavior in H2O, import ...

2009

In vitro anticancer activity and biologically relevant metabolization of organometallic ruthenium complexes with carbohydrate-based ligands

Paul Joseph Dyson, Christian Hartinger, Alexey Nazarov, Olivier Pierre Zava, Michael Groessl, Frédéric Schmitt, Muhammad Hanif

The synthesis and in vitro anticancer activity of dihalo(η6-p-cymene)(3,5,6-bicyclophosphite-α-D-glucofuranoside)ruthenium(II) complexes are described. The compds. were characterized by NMR spectroscopy and ESI mass spectrometry, and the mol. structures of ...

2008

A Polyoxyethylene-Substituted Bimetallic Europium Helicate for Luminescent Staining of Living Cells

Jean-Claude Bünzli, Anne-Sophie Chauvin, Caroline Vandevyver, Bo Song, Steve Comby

The homoditopic ligand

H_2L^{C3}

has been designed to form neutral triple-stranded bimetallic helicates of overall composition [

Ln_2(L^{C3})_3

]. The grafting of the polyoxyethylene fragments ensures water solubility and also favors cell penetration whi ...

2007

Platinum(II) Complexes with O,S Bidentate Ligands: Biophysical Characterization, Antiproliferative Activity, and Crystallographic Evidence of Protein Binding

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Photoactive sawhorse-type diruthenium tetracarbonyl complexes

Encapsulation of hydrophobic pyrenyl-cycloplatinate complexes within a water-soluble arene ruthenium metalla-cage

Highly cytotoxic trithiophenolatodiruthenium complexes of the type [(eta(6)-p-MeC6H4Pr (i) )(2)Ru-2(SC6H4-p-X)(3)](+): synthesis, molecular structure, electrochemistry, cytotoxicity, and glutathione oxidation potential

Enhancement of irradiation effects on cancer cells by cross-linked dextran-coated iron oxide (CLIO) nanoparticles

Functional analysis and knock‐down phenotype of BCL9 and BCL9L in cancer cell lines

Highly Cytotoxic Copper(II) Complexes with Modified Paullone Ligands

Maltol-Derived Ruthenium-Cymene Complexes with Tumor Inhibiting Properties: The Impact of Ligand-Metal Bond Stability on Anticancer Activity In Vitro

A Novel Cytotoxic Cerium Complex: Aquatrichloridobis(1,10-phenanthroline)cerium(III) (KP776). Synthesis, Characterization, Behavior in H2O, Binding towards Biomolecules, and Antiproliferative Activity

In vitro anticancer activity and biologically relevant metabolization of organometallic ruthenium complexes with carbohydrate-based ligands

A Polyoxyethylene-Substituted Bimetallic Europium Helicate for Luminescent Staining of Living Cells

Photoactive sawhorse-type diruthenium tetracarbonyl complexes

Functional analysis and knock‐down phenotype of BCL9 and BCL9L in cancer cell lines

Highly Cytotoxic Copper(II) Complexes with Modified Paullone Ligands

Encapsulation of hydrophobic pyrenyl-cycloplatinate complexes within a water-soluble arene ruthenium metalla-cage

A Novel Cytotoxic Cerium Complex: Aquatrichloridobis(1,10-phenanthroline)cerium(III) (KP776). Synthesis, Characterization, Behavior in H2O, Binding towards Biomolecules, and Antiproliferative Activity

Maltol-Derived Ruthenium-Cymene Complexes with Tumor Inhibiting Properties: The Impact of Ligand-Metal Bond Stability on Anticancer Activity In Vitro

Highly cytotoxic trithiophenolatodiruthenium complexes of the type [(eta(6)-p-MeC6H4Pr (i) )(2)Ru-2(SC6H4-p-X)(3)](+): synthesis, molecular structure, electrochemistry, cytotoxicity, and glutathione oxidation potential

A Polyoxyethylene-Substituted Bimetallic Europium Helicate for Luminescent Staining of Living Cells

Enhancement of irradiation effects on cancer cells by cross-linked dextran-coated iron oxide (CLIO) nanoparticles

In vitro anticancer activity and biologically relevant metabolization of organometallic ruthenium complexes with carbohydrate-based ligands