EpigeneticsIn biology, epigenetics is the study of stable changes in cell function (known as marks) that do not involve alterations in the DNA sequence. The Greek prefix epi- (ἐπι- "over, outside of, around") in epigenetics implies features that are "on top of" or "in addition to" the traditional genetic basis for inheritance. Epigenetics most often involves changes that affect the regulation of gene expression, and that persist through cellular division.
Projective moduleIn mathematics, particularly in algebra, the class of projective modules enlarges the class of free modules (that is, modules with basis vectors) over a ring, by keeping some of the main properties of free modules. Various equivalent characterizations of these modules appear below. Every free module is a projective module, but the converse fails to hold over some rings, such as Dedekind rings that are not principal ideal domains.
Module (mathematics)In mathematics, a module is a generalization of the notion of vector space in which the field of scalars is replaced by a ring. The concept of module generalizes also the notion of abelian group, since the abelian groups are exactly the modules over the ring of integers. Like a vector space, a module is an additive abelian group, and scalar multiplication is distributive over the operation of addition between elements of the ring or module and is compatible with the ring multiplication.
DNADeoxyribonucleic acid (diːˈɒksᵻˌraɪboʊnjuːˌkliːᵻk,_-ˌkleɪ-; DNA) is a polymer composed of two polynucleotide chains that coil around each other to form a double helix. The polymer carries genetic instructions for the development, functioning, growth and reproduction of all known organisms and many viruses. DNA and ribonucleic acid (RNA) are nucleic acids. Alongside proteins, lipids and complex carbohydrates (polysaccharides), nucleic acids are one of the four major types of macromolecules that are essential for all known forms of life.
Activator (genetics)A transcriptional activator is a protein (transcription factor) that increases transcription of a gene or set of genes. Activators are considered to have positive control over gene expression, as they function to promote gene transcription and, in some cases, are required for the transcription of genes to occur. Most activators are DNA-binding proteins that bind to enhancers or promoter-proximal elements. The DNA site bound by the activator is referred to as an "activator-binding site".
Free moduleIn mathematics, a free module is a module that has a basis, that is, a generating set consisting of linearly independent elements. Every vector space is a free module, but, if the ring of the coefficients is not a division ring (not a field in the commutative case), then there exist non-free modules. Given any set S and ring R, there is a free R-module with basis S, which is called the free module on S or module of formal R-linear combinations of the elements of S. A free abelian group is precisely a free module over the ring Z of integers.
Topologically associating domainA topologically associating domain (TAD) is a self-interacting genomic region, meaning that DNA sequences within a TAD physically interact with each other more frequently than with sequences outside the TAD. The median size of a TAD in mouse cells is 880 kb, and they have similar sizes in non-mammalian species. Boundaries at both side of these domains are conserved between different mammalian cell types and even across species and are highly enriched with CCCTC-binding factor (CTCF) and cohesin.
Finitely generated moduleIn mathematics, a finitely generated module is a module that has a finite generating set. A finitely generated module over a ring R may also be called a finite R-module, finite over R, or a module of finite type. Related concepts include finitely cogenerated modules, finitely presented modules, finitely related modules and coherent modules all of which are defined below. Over a Noetherian ring the concepts of finitely generated, finitely presented and coherent modules coincide.
Category of modulesIn algebra, given a ring R, the category of left modules over R is the whose are all left modules over R and whose morphisms are all module homomorphisms between left R-modules. For example, when R is the ring of integers Z, it is the same thing as the . The category of right modules is defined in a similar way. One can also define the category of bimodules over a ring R but that category is equivalent to the category of left (or right) modules over the enveloping algebra of R (or over the opposite of that).
Sheaf of modulesIn mathematics, a sheaf of O-modules or simply an O-module over a ringed space (X, O) is a sheaf F such that, for any open subset U of X, F(U) is an O(U)-module and the restriction maps F(U) → F(V) are compatible with the restriction maps O(U) → O(V): the restriction of fs is the restriction of f times that of s for any f in O(U) and s in F(U). The standard case is when X is a scheme and O its structure sheaf. If O is the constant sheaf , then a sheaf of O-modules is the same as a sheaf of abelian groups (i.
