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Clinically compliant cryopreservation of differentiated retinal pigment epithelial cells
Related publications (40)
Programming of Multicellular Patterning with Mechano-Chemically Microstructured Cell Niches
Multicellular patterning of stem-cell-derived tissue models is commonly achieved via self-organizing activities triggered by exogenous morphogenetic stimuli. However, such tissue models are prone to stochastic behavior, limiting the reproducibility of cell ...
WILEY2023ISSCR standards for the use of human stem cells in basic research
The laboratory culture of human stem cells seeks to capture a cellular state as an in vitro surrogate of a biological system. For the results and outputs from this research to be accurate, meaning-ful, and durable, standards that ensure reproducibility and ...
Cambridge2023Retrospectives on Three Decades of Safe Clinical Experience with Allogeneic Dermal Progenitor Fibroblasts: High Versatility in Topical Cytotherapeutic Care
Corinne Scaletta, Philippe Abdel Sayed, Nathalie Hirt-Burri, Alexis Laurent
Allogeneic dermal progenitor fibroblasts constitute cytotherapeutic contenders for modern cutaneous regenerative medicine. Based on advancements in the relevant scientific, technical, and regulatory fields, translational developments have slowly yet steadi ...
MDPI2023Countering T cell exhaustion and senescence for enhanced adoptive T cell therapies against solid tumors
CAR-T cell therapy has shown remarkable success in treating hematopoietic malignancies, but its efficacy in solid tumors is limited by T cell dysfunction, including exhaustion and senescence. In this study, we designed metabolically armored CAR-T cells to ...
EPFL2023HTATIP2 regulates arteriogenic activity in monocytes from patients with limb ischemia
Michele De Palma, Mario Leonardo Squadrito
Use of autologous cells isolated from elderly patients with multiple comorbidities may account for the modest efficacy of cell therapy in patients with chronic limb threatening ischemia (CLTI). We aimed to determine whether proarteriogenic monocyte/macroph ...
Ann Arbor2023Autologous and Allogeneic Cytotherapies for Large Knee (Osteo)Chondral Defects: Manufacturing Process Benchmarking and Parallel Functional Qualification
Corinne Scaletta, Sandra Jaccoud, Philippe Abdel Sayed, Nathalie Hirt-Burri, Robin Martin, Salim Elias Darwiche, Cédric Peneveyre, Annick Jeannerat, Alexis Laurent
Cytotherapies are often necessary for the management of symptomatic large knee (osteo)-chondral defects. While autologous chondrocyte implantation (ACI) has been clinically used for 30 years, allogeneic cells (clinical-grade FE002 primary chondroprogenitor ...
Basel2023Generation of Human iPSC-Derived Neurons on Nanowire Arrays Featuring Varying Lengths, Pitches, and Diameters
Anna Fontcuberta i Morral, Wonjong Kim
Nanowire (NW) arrays interfaced with biological cells have been demonstrated to be potent tools for advanced applications such as sensing, stimulation, or drug delivery. Many implementations, however, have so far only been studied with rather robust basic ...
WILEY2022Molecular profiling of stem cell-derived retinal pigment epithelial cell differentiation established for clinical translation
Gioele La Manno, Alex Russell Lederer, Irina Khven
Human embryonic stem cell-derived retinal pigment epithelial cells (hESC-RPE) are a promising cell source to treat age-related macular degeneration (AMD). Despite several ongoing clinical studies, a detailed mapping of transient cellular states during in v ...
CELL PRESS2022Engineered signaling centers for the spatially controlled patterning of human pluripotent stem cells
Matthias Lütolf, Felix Naef, Yoji Tabata, Eric Paquet, François Réal Rivest, Ambroise Roger Vuaridel, Andrea Manfrin
Signaling centers, localized groups of cells that secrete morphogens, play a key role in early development and organogenesis by orchestrating spatial cell fate patterning. Here we present a microfluidic approach that exposes human pluripotent stem cell (hP ...
NATURE PUBLISHING GROUP2019Bioengineering the Human Muscle Stem-Cell Niche for Therapeutic Applications
In spite of decades of research, no feasible method for obtaining sufficient numbers of uncommitted muscle stem cells (MuSCs) for therapy of degenerative muscle diseases exists. One of the most fundamental problems associated with stem cell therapy of musc ...
EPFL2019