Chaire Merck Serono en oncologie

Chair

The Chaire Merck Serono en oncologie, led by the Hanahan Lab, focuses on investigating tumor development and progression using genetically engineered mouse models of cancer. Their research aims to elucidate the mechanisms underlying multi-step tumorigenesis and malignant progression, with a strategic goal to develop new therapeutic strategies for improving the treatment of human cancers. The lab's current research areas include melanoma, glioblastoma, pancreatic cancer, and squamous carcinomas elicited by human papillomaviruses. They study acquired capabilities of cancer cells, such as resistance to programmed cell death, tumor angiogenesis, invasion, and metastasis, with a particular emphasis on the role of the tumor microenvironment and accessory cells in promoting malignant disease. Additionally, the lab investigates adaptive resistance mechanisms to therapies targeting hallmark capabilities, offering insights into potential combinatorial therapies to overcome drug resistance.

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Metastasis

Metastasis is a pathogenic agent's spread from an initial or primary site to a different or secondary site within the host's body; the term is typically used when referring to metastasis by a cancerous tumor. The newly pathological sites, then, are metastases (mets). It is generally distinguished from cancer invasion, which is the direct extension and penetration by cancer cells into neighboring tissues. Cancer occurs after cells are genetically altered to proliferate rapidly and indefinitely.

Cancer

Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. These contrast with benign tumors, which do not spread. Possible signs and symptoms include a lump, abnormal bleeding, prolonged cough, unexplained weight loss, and a change in bowel movements. While these symptoms may indicate cancer, they can also have other causes. Over 100 types of cancers affect humans. Tobacco use is the cause of about 22% of cancer deaths.