Prof. Radtke Group

The Radtke Lab at EPFL, led by Prof. Radtke, focuses on understanding the molecular mechanisms that regulate stem cell maintenance, lineage commitment, and differentiation in self-renewing systems like the hematopoietic system, skin, and gut. They investigate how signaling pathways such as Shh, Wnt, and Notch control these processes and how their dysregulation can lead to tumorigenesis. Particularly, they study the Notch signaling pathway's roles in different self-renewing tissues and cancer, aiming to identify novel therapeutic targets and improve strategies for treating tumorigenesis.