Publications related to The Bucher Group

Nonlinearity arising from noncooperative transcription factor binding enhances negative feedback and promotes genetic oscillations

Andrew Charles Oates, Daniele Soroldoni

We study the effects of multiple binding sites in the promoter of a genetic oscillator. We evaluate the regulatory function of a promoter with multiple binding sites in the absence of cooperative binding, and consider different hypotheses for how the numbe ...

2014

Two distinct promoter architectures centered on dynamic nucleosomes control ribosomal protein gene transcription

Felix Naef, Sebastian Maerkl, Jacques Rougemont, Nicolas Dénervaud, Marcel Geertz, Philippe Jacquet

In yeast, ribosome production is controlled transcriptionally by tight coregulation of the 138 ribosomal protein genes (RPGs). RPG promoters display limited sequence homology, and the molecular basis for their coregulation remains largely unknown. Here we ...

Cold Spring Harbor Laboratory Press2014

Fifteen years SIB Swiss Institute of Bioinformatics: life science databases, tools and support

Jacques Rougemont, Philipp Bucher, Mauro Delorenzi, Heinz Stockinger, Ioannis Xenarios, Olivier Michielin, Amos Bairoch

The SIB Swiss Institute of Bioinformatics (www.isb-sib.ch) was created in 1998 as an institution to foster excellence in bioinformatics. It is renowned worldwide for its databases and software tools, such as UniProtKB/Swiss-Prot, PROSITE, SWISS-MODEL, STRI ...

Oxford University Press2014

Conservation and Divergence of Regulatory Strategies at Hox Loci and the Origin of Tetrapod Digits

Denis Duboule, Marion Leleu, Daniël Noordermeer

The evolution of tetrapod limbs from fish fins enabled the conquest of land by vertebrates and thus represents a key step in evolution. Despite the use of comparative gene expression analyses, critical aspects of this transformation remain controversial, i ...

Public Library Science2014

As Time Goes by: KRABs Evolve to KAP Endogenous Retroelements

Didier Trono, Michaël Imbeault

Retroelements, constituting about 50% of the human genome, both contribute to its evolution and threaten its integrity and are thus silenced during development. Jacobs et al. (2014) identify sequence-specific KRAB-ZNF proteins that repress subsets of L1 an ...

Elsevier2014

Multiciliogenesis: multicilin directs transcriptional activation of centriole formation

Pierre Gönczy, Fernando Romero Balestra

During differentiation of multiciliated cells, numerous centrioles are generated in each cell to act as templates for the formation of a corresponding number of cilia. A new study reveals that multicilin, a protein required for multiciliogenesis, is a key ...

Cell Press2014

Functional characterization of the TERRA transcriptome at damaged telomeres

Joachim Lingner, Jacques Rougemont, Antonio Porro, Julien Delafontaine, Sascha Feuerhahn

Telomere deprotection occurs during tumorigenesis and aging upon telomere shortening or loss of the telomeric shelterin component TRF2. Deprotected telomeres undergo changes in chromatin structure and elicit a DNA damage response (DDR) that leads to cellul ...

Nature Publishing Group2014

Nuclear Factor I genomic binding associates with chromatin boundaries

Giovanni Dietler, Giovanna Ambrosini, Jan Kerschgens, Philipp Bucher, Nicolas Mermod, Petar Pjanic, Armelle Gaussin

Background: The Nuclear Factor I (NFI) family of DNA binding proteins (also called CCAAT box transcription factors or CTF) is involved in both DNA replication and gene expression regulation. Using chromatin immuno-precipitation and high throughput sequenci ...

BioMed Central2013

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The Bucher Group

Nonlinearity arising from noncooperative transcription factor binding enhances negative feedback and promotes genetic oscillations

Two distinct promoter architectures centered on dynamic nucleosomes control ribosomal protein gene transcription

Fifteen years SIB Swiss Institute of Bioinformatics: life science databases, tools and support

Sumoylated Human Histone H4 Prevents Chromatin Compaction by Inhibiting Long-range Internucleosomal Interactions

Conservation and Divergence of Regulatory Strategies at Hox Loci and the Origin of Tetrapod Digits

As Time Goes by: KRABs Evolve to KAP Endogenous Retroelements

Multiciliogenesis: multicilin directs transcriptional activation of centriole formation

Functional characterization of the TERRA transcriptome at damaged telomeres

Computational analysis of ultraconserved non-coding DNA elements in vertebrate genomes

Nuclear Factor I genomic binding associates with chromatin boundaries

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Chat with Graph Search

Two distinct promoter architectures centered on dynamic nucleosomes control ribosomal protein gene transcription

Nonlinearity arising from noncooperative transcription factor binding enhances negative feedback and promotes genetic oscillations

Fifteen years SIB Swiss Institute of Bioinformatics: life science databases, tools and support

Sumoylated Human Histone H4 Prevents Chromatin Compaction by Inhibiting Long-range Internucleosomal Interactions

Conservation and Divergence of Regulatory Strategies at Hox Loci and the Origin of Tetrapod Digits

Functional characterization of the TERRA transcriptome at damaged telomeres

As Time Goes by: KRABs Evolve to KAP Endogenous Retroelements

Multiciliogenesis: multicilin directs transcriptional activation of centriole formation

Computational analysis of ultraconserved non-coding DNA elements in vertebrate genomes

Nuclear Factor I genomic binding associates with chromatin boundaries