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Concept
Cultured neuronal network
Résumé
A cultured neuronal network is a cell culture of neurons that is used as a model to study the central nervous system, especially the brain. Often, cultured neuronal networks are connected to an input/output device such as a multi-electrode array (MEA), thus allowing two-way communication between the researcher and the network. This model has proved to be an invaluable tool to scientists studying the underlying principles behind neuronal learning, memory, plasticity, connectivity, and information processing.
Cultured neurons are often connected via computer to a real or simulated robotic component, creating a hybrot or animat, respectively. Researchers can then thoroughly study learning and plasticity in a realistic context, where the neuronal networks are able to interact with their environment and receive at least some artificial sensory feedback. One example of this can be seen in the Multielectrode Array Art (MEART) system developed by the Potter Research Group at the Georgia Institute of Technology in collaboration with SymbioticA, The Centre for Excellence in Biological Art, at the University of Western Australia. Another example can be seen in the neurally controlled animat.
The use of cultured neuronal networks as a model for their in vivo counterparts has been an indispensable resource for decades. It allows researchers to investigate neuronal activity in a much more controlled environment than would be possible in a live organism. Through this mechanism researchers have gleaned important information about the mechanisms behind learning and memory.
A cultured neuronal network allows researchers to observe neuronal activity from several vantage points. Electrophysiological recording and stimulation can take place either across the network or locally via an MEA, and the network development can be visually observed using microscopy techniques. Moreover, chemical analysis of the neurons and their environment is more easily accomplished than in an in vivo setting.
Cultured neuronal networks are by definition disembodied cultures of neurons.
Source officielle
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