Publications associées à Wnt (protéines)

Carbon, Hydrogen, and Nitrogen Isotope Fractionation Trends in N-Nitrosodimethylamine Reflect the Formation Pathway during Chloramination of Tertiary Amines

Urs von Gunten, Stephanie Spahr

Assessing the precursors and reactions leading to the carcinogenic N-nitrosodimethylamine (NDMA) during drinking water disinfection is a major challenge. Here, we investigate whether changes of C-13/C-12,H-2/H-1, and N-15/N-14 ratios of NDMA give rise to i ...

American Chemical Society2017

In vivo reprogramming of non-mammary cells to an epithelial cell fate is independent of amphiregulin signaling

Cathrin Brisken, Stéphanie Cagnet

AREG-/- mice demonstrate impaired mammary development and form only rudimentary ductal epithelial trees, however, AREG-/- glands are still capable of undergoing alveologenesis and lactogenesis during pregnancy. Transplantation of AREG-/- mammary epithelial ...

Company of Biologists2017

Biogenesis of the mitochondrial DNA inheritance machinery in the mitochondrial outer membrane of Trypanosoma brucei

Mathilde Stéphanie Willemin, André Schneider

Mitochondria cannot form de novo but require mechanisms that mediate their inheritance to daughter cells. The parasitic protozoan Trypanosoma brucei has a single mitochondrion with a single-unit genome that is physically connected across the two mitochondr ...

2017

Conditional Selection of Genomic Alterations Dictates Cancer Evolution and Oncogenic Dependencies

Elisa Oricchio, Daniele Tavernari, Mohammad Sadegh Saghafinia, Elena Battistello, Stephanie Jocelyne Sungalee, Franck Claude Raynaud, Giovanni Ciriello, Marco Mina, Titouan Laessle

Cancer evolves through the emergence and selection of molecular alterations. Cancer genome profiling has revealed that specific events are more or less likely to be co-selected, suggesting that the selection of one event depends on the others. However, the ...

Cell Press2017

Gene regulatory mechanisms underlying the intestinal innate immune response

Bart Deplancke, Antonio Carlos Alves Meireles Filho

In the mammalian gastrointestinal tract, distinct types of cells, including epithelial cells and macrophages, collaborate to eliminate ingested pathogens while striving to preserve the commensal microbiota. The underlying innate immune response is driven b ...

Elsevier2017

Wnt Ligands Secreted by Subepithelial Mesenchymal Cells Are Essential for the Survival of Intestinal Stem Cells and Gut Homeostasis

Michel Aguet, Andreas Eduard Moor

Targeting of Wnt signaling represents a promising anti-cancer therapy. However, the consequences of systemically attenuating the Wnt pathway in an adult organism are unknown. Here, we globally prevent Wnt secretion by genetically ablating Wntless. We find ...

Elsevier2016

The fusion protein SS18-SSX1 employs core Wnt pathway transcription factors to induce a partial Wnt signature in synovial sarcoma

Michel Aguet, Ivan Stamenkovic, Tanja Petricevic

Expression of the SS18/SYT-SSX fusion protein is believed to underlie the pathogenesis of synovial sarcoma (SS). Recent evidence suggests that deregulation of the Wnt pathway may play an important role in SS but the mechanisms whereby SS18-SSX might affect ...

Nature Publishing Group2016

Phage selection of peptide macrocycles against b-catenin to interfere with Wnt signaling

Christian Heinis, Pierre Vincent Dessen, Davide Bertoldo, Maola Khan Mohammad Golam

Upregulation of b-catenin, the primary mediator of the Wnt signaling pathway, plays an important role in the tumorigenesis of several types of human cancer. Targeting b-catenin to interfere with its ability to serve as a translational co-activator is consi ...

2016

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Wnt (protéines)

Carbon, Hydrogen, and Nitrogen Isotope Fractionation Trends in N-Nitrosodimethylamine Reflect the Formation Pathway during Chloramination of Tertiary Amines

In vivo reprogramming of non-mammary cells to an epithelial cell fate is independent of amphiregulin signaling

Biogenesis of the mitochondrial DNA inheritance machinery in the mitochondrial outer membrane of Trypanosoma brucei

Conditional Selection of Genomic Alterations Dictates Cancer Evolution and Oncogenic Dependencies

Gene regulatory mechanisms underlying the intestinal innate immune response

Wnt Ligands Secreted by Subepithelial Mesenchymal Cells Are Essential for the Survival of Intestinal Stem Cells and Gut Homeostasis

WIF1 re-expression in glioblastoma inhibits migration through attenuation of non-canonical WNT signaling by downregulating the lncRNA MALAT1

The fusion protein SS18-SSX1 employs core Wnt pathway transcription factors to induce a partial Wnt signature in synovial sarcoma

Phage selection of peptide macrocycles against b-catenin to interfere with Wnt signaling

Proteome-Wide Effect of 17-beta-Estradiol and Lipoxin A(4) in an Endometriotic Epithelial Cell Line

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Gene regulatory mechanisms underlying the intestinal innate immune response

WIF1 re-expression in glioblastoma inhibits migration through attenuation of non-canonical WNT signaling by downregulating the lncRNA MALAT1

Phage selection of peptide macrocycles against b-catenin to interfere with Wnt signaling

The fusion protein SS18-SSX1 employs core Wnt pathway transcription factors to induce a partial Wnt signature in synovial sarcoma

Proteome-Wide Effect of 17-beta-Estradiol and Lipoxin A(4) in an Endometriotic Epithelial Cell Line

Carbon, Hydrogen, and Nitrogen Isotope Fractionation Trends in N-Nitrosodimethylamine Reflect the Formation Pathway during Chloramination of Tertiary Amines

Conditional Selection of Genomic Alterations Dictates Cancer Evolution and Oncogenic Dependencies

Biogenesis of the mitochondrial DNA inheritance machinery in the mitochondrial outer membrane of Trypanosoma brucei

In vivo reprogramming of non-mammary cells to an epithelial cell fate is independent of amphiregulin signaling

Wnt Ligands Secreted by Subepithelial Mesenchymal Cells Are Essential for the Survival of Intestinal Stem Cells and Gut Homeostasis