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The study of genomic inversions (or reversals) has been a mainstay of computational genomics for nearly 20 years. After the initial breakthrough of Hannenhalli and Pevzner, who gave the first polynomial-time algorithm for sorting signed permutations by inv ...
DNA is a long polymer with the form of a double helix of about two nanometers diameter (2.10-9 meters). It is composed of nucleotides whose sequence carries the information of heredity. The four possible nucleotides have slightly different geometries, and ...
We use cryo-electron microscopy to compare 3D shapes of 158 bp long DNA minicircles that differ only in the sequence within an 18 bp block containing either a TATA box or a catabolite activator protein binding site. We present a sorting algorithm that corr ...
Whether different brain networks are involved in generating unimanual responses to a simple visual stimulus presented in the ipsilateral versus contralateral hemifield remains a controversial issue. Visuo-motor routing was investigated with event-related f ...
An ever more complete picture of the organization and function of the endocytic pathway is emerging. New mechanisms, and in particular lipid- based mechanisms that couple membrane dynamics and sorting, are being unraveled. But the final picture is still co ...
Starting with a formal problem specification, we show how to progressively achieve a parallel distributed solution, using convenient transformations of specifications. In order to achieve a solution, we use rewriting techniques applied in the context of tr ...
This paper addresses the problem of broadcasting messages in a reliable and totally ordered manner when processes and channels may crash and recover, or crash and never recover. We present a suite of specifications of reliable and total order broadcast pri ...
Alginate gel formation on-chip is presented in the first part of this thesis. The technique allows immobilization, and release, of biological cells on-chip. Furthermore, via layer by layer deposition, a locally heterogeneous environment can be generated at ...
Tyrosinase is a type I membrane protein found in melanosomes, which are lysosomal-like organelles and specific for pigment cells. A mutation of mouse tyrosinase, platinum (cp), leads to truncation of tyrosinase's cytosolic tail, and results in misrouting t ...