Concept

Plaque neurale

Publications associées (65)

Heterogeneity and developmental dynamics of mammalian neocortical progenitors

Gioele La Manno, Antonio Herrera Camacho, Leila Haj Abdullah Alieh

The central nervous system develops from a pool of neural progenitors which, depending on their location and time of division, generate cells committed to differentiate into specific kinds of neurons or glia. In the last decades, the developmental neurobio ...

Amsterdam2023

Preparation of Single-Somite Explants from Zebrafish Embryos

Andrew Charles Oates, Sundar Ram Naganathan

The body axis of vertebrate embryos is periodically subdivided into 3D multicellular units called somites. While genetic oscillations and molecular prepatterns determine the initial length-scale of somites, mechanical processes have been implicated in sett ...

JOURNAL OF VISUALIZED EXPERIMENTS2022

Towards engineering an artificial neural tube

Jisoo Park

In this thesis, I present a self-organizing neural tube organoid that is strikingly similar in morphology, cell-type composition, and patterning to the mouse embryonic neural tube. When exposed to a sequence of epiblast culture conditions and neural differ ...

EPFL2021

Soft materials and technologies for neural interfaces

Michael Shur

Implantable neural interfaces are an emerging concept which is revolutionizing various domains of medicine and rehabilitation. However, the long-term efficiency and reliability of these devices is often limited, mainly attributed to the fundamental differe ...

EPFL2021

In vitro modeling of early mouse development

Mehmet Ugur Girgin

Previous attempts to recapitulate embryogenesis in a developmentally relevant context started with aggregates composed of a few thousand ESCs, termed embryoid bodies (EB), that upon induction of differentiation reveal a surprising level of autonomous cell ...

EPFL2020

Tp63-expressing adult epithelial stem cells cross lineages boundaries revealing latent hairy skin competence

Yann Barrandon, Ariane Rochat, Stéphanie Claudinot, Paola Bonfanti, Daniel-Alexandre Littman, Christèle Gonneau

The formation of hair follicles, a landmark of mammals, requires complex mesenchymal-epithelial interactions and it is commonly believed that embryonic epidermal cells are the only cells that can respond to hair follicle morphogenetic signals in vivo. Here ...

NATURE RESEARCH2020

Wnt-controlled sphingolipids modulate Anthrax Toxin Receptor palmitoylation to regulate oriented mitosis in zebrafish

Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami

Oriented cell division is a fundamental mechanism to control asymmetric stem cell division, neural tube elongation and body axis extension, among other processes. During zebrafish gastrulation, when the body axis extends, dorsal epiblast cells display divi ...

NATURE PUBLISHING GROUP2020

Tail Bud Progenitor Activity Relies on a Network Comprising Gdf11, Lin28, and Hox13 Genes

Denis Duboule

During the trunk-to-tail transition, axial progenitors relocate from the epiblast to the tail bud. Here, we show that this process entails a major regulatory switch, bringing tail bud progenitors under Gdf11 signaling control. Gdf11 mutant embryos have an ...

CELL PRESS2019

Glycosphingolipid metabolic reprogramming drives neural differentiation

Giovanni D'Angelo, Riccardo Rizzo

Neural development is accomplished by differentiation events leading to metabolic reprogramming. Glycosphingolipid metabolism is reprogrammed during neural development with a switch from globo- to ganglio-series glycosphingolipid production. Failure to exe ...

2018

Théâtre Vidy Lausanne - A Double-Layered Timber Folded Plate Structure

Yves Weinand, Julien Gamerro, Christopher Werner Matthias Robeller

This article describes the first full-scale realization of a double-layered, folded plate structure (DLFP), for a new hall for the Théâtre Vidy Lausanne. (Fig. 1). Enabled by a novel double-tenon connection technology, the shape of the components simultane ...

2017

Graph Chatbot

Chattez avec Graph Search

Posez n’importe quelle question sur les cours, conférences, exercices, recherches, actualités, etc. de l’EPFL ou essayez les exemples de questions ci-dessous.

AVERTISSEMENT : Le chatbot Graph n'est pas programmé pour fournir des réponses explicites ou catégoriques à vos questions. Il transforme plutôt vos questions en demandes API qui sont distribuées aux différents services informatiques officiellement administrés par l'EPFL. Son but est uniquement de collecter et de recommander des références pertinentes à des contenus que vous pouvez explorer pour vous aider à répondre à vos questions.

Connectez-vous pour utiliser Chat avec Graph Search