Concept

Maladie génétique du métabolisme des glucides

Publications associées (76)

Diagnosis of muscular dystrophies at the nanometer scale

Andrzej Kulik, Thibault Adrien Kuntzer, Stefania Puttini

The diagnosis of muscular dystrophies or the assessment of the functional benefit of gene or cell therapies can be difficult, especially for poorly accessible muscles, and it often lacks a single-fiber resolution. In the present study, we evaluated whether ...

World Muscular Society / Elsevier2009

In vivo magnetic resonance studies of glycogen and hyperpolarized lithium in the rat brain

Ruud van Heeswijk

Nuclear magnetic resonance (NMR) is used for a large array of applications, ranging from chemical characterization to oil drilling to medical imaging. In these fields NMR is used as an investigational tool, but new techniques and applications are continuou ...

EPFL2009

Non-invasive quantification of brain glycogen absolute concentration

Rolf Gruetter, Lijing Xin, Hongxia Lei, Ruud van Heeswijk, Hanne Frenkel, Sabrina Laus

The only currently available method to measure brain glycogen in vivo is C-13 NMR spectroscopy. Incorporation of C-13-labeled glucose (Glc) is necessary to allow glycogen measurement, but might be affected by turnover changes. Our aim was to measure glycog ...

Wiley-Blackwell2008

Modulation of astrocytic metabolic phenotype by proinflammatory cytokines

Pierre Magistretti, Igor Allaman

Astrocytes play an important role in nervous system homeostasis. In particular, they contribute to the regulation of local energy metabolism and to oxidative stress defence. In previous experiments, we showed that long-term treatment with interleukin 1alph ...

2008

Human brain glycogen content and metabolism: Implications on its role in brain energy metabolism

Rolf Gruetter, Ajay Kumar

The adult brain relies on glucose for its energy needs and stores it in the form of glycogen, primarily in astrocytes. Animal and culture studies indicate that brain glycogen may support neuronal function when the glucose supply from the blood is inadequat ...

2007

Direct validation of in vivo localized 13C MRS measurements of brain glycogen

Rolf Gruetter, Hongxia Lei

With the use of localized 13C MRS in conjunction with [1-(13)C]-D-glucose infusion, it is possible to study brain glycogen metabolism in vivo. The purpose of this study was to validate in vivo 13C MRS measurements by comparing them with results from a stan ...

Wiley-Blackwell2007

Metabolic compartmentalization in the human cortex and hippocampus: evidence for a cell- and region-specific localization of lactate dehydrogenase 5 and pyruvate dehydrogenase

Pierre Magistretti, Luc Pellerin

BACKGROUND: For a long time now, glucose has been thought to be the main, if not the sole substrate for brain energy metabolism. Recent data nevertheless suggest that other molecules, such as monocarboxylates (lactate and pyruvate mainly) could be suitable ...

2007

Neuregulins increase mitochondrial oxidative capacity and insulin sensitivity in skeletal muscle cells

Carlos Canto Alvarez

Neuregulins are growth factors that are essential for myogenesis and regulate muscle metabolism. The addition of a recombinant neuregulin-1 isoform, heregulin-beta1(177-244) (Hrg), containing 3 nmol/l of the bioactive epidermal growth factor-like domain, t ...

2007

Effect of chronic hypoglycaemia on glucose concentration and glycogen content in rat brain: A localized 13C NMR study

Rolf Gruetter, Hongxia Lei

While chronic hypoglycaemia has been reported to increase unidirectional glucose transport across the blood-brain barrier (BBB) and to increase GLUT1 expression at the endothelium, the effect on steady-state brain d-glucose and brain glycogen content is cu ...

Wiley-Blackwell2006

Biochemical quantification of total brain glycogen concentration in rats under different glycemic states

Rolf Gruetter

All 13C NMR studies of brain glycogen to date relied on observing the incorporation of 13C label into glycogen, and thus interpretation was potentially affected by changes in 13C label turnover rates. The goal of this study was to quantify total brain glyc ...

2006

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