Concept

Maladie génétique du métabolisme des glucides

Publications associées (76)

Ex vivo lentivirus transduction and immediate transplantation of uncultured hepatocytes for treating hyperbilirubinemic Gunn rat

BACKGROUND: Ex vivo liver gene therapy provides an attractive alternative to orthotopic liver transplantation for the treatment of liver diseases. We previously reported a protocol in which human primary hepatocytes are highly transduced in Suspension with ...

Lippincott, Williams & Wilkins2006

Improving user comfort in haptic virtual environments through gravity compensation

Daniel Thalmann, Frédéric Vexo, Renaud Ott

Our experience with a Haptic Workstation™ has shown that this device is uncomfortable to use during long sessions. The main reason is the uncomfortable posture of the arms, which must be kept outstretched horizontally while supporting the weight of an exos ...

2005

Brain lactate kinetics: Modeling evidence for neuronal lactate uptake upon activation

Pierre Magistretti, Luc Pellerin

A critical issue in brain energy metabolism is whether lactate produced within the brain by astrocytes is taken up and metabolized by neurons upon activation. Although there is ample evidence that neurons can efficiently use lactate as an energy substrate, ...

2005

Glucocorticoids modulate neurotransmitter-induced glycogen metabolism in cultured cortical astrocytes

Pierre Magistretti, Igor Allaman, Luc Pellerin

Glucocorticoids (GC) are considered as key modulators of glycogen homeostasis in peripheral tissues, but their role in the central nervous system has only partially been characterized. Exposure of primary cultures of cortical astrocytes to dexamethasone (D ...

2004

Plasmodium falciparum glycogen synthase kinase-3: molecular model, expression, intracellular localisation and selective inhibitors

Worldwide increasing resistance of Plasmodium falciparum to common anti-malaria agents calls for the urgent identification of new drugs. Glycogen synthase kinase-3 (GSK-3) represents a potential screening target for the identification of such new compounds ...

2004

Direct, noninvasive measurement of brain glycogen metabolism in humans

Rolf Gruetter

The concentration and metabolism of the primary carbohydrate store in the brain, glycogen, is unknown in the conscious human brain. This study reports the first direct detection and measurement of glycogen metabolism in the human brain, which was achieved ...

Elsevier2003

Effect of hypoglycemia on brain glycogen metabolism in vivo

Rolf Gruetter

The brain contains a small but significant amount of glycogen, which has long been considered to play an insignificant role in the brain. In this study, brain glycogen metabolism was measured using (13)C NMR spectroscopy at 9.4 T. Brain glycogen metabolism ...

Wiley-Blackwell2003

Sleep deprivation modulates brain mRNAs encoding genes of glycogen metabolism

Pierre Magistretti, Igor Allaman, Jean-Marie Petit

Replenishment of brain glycogen stores depleted during waking has been suggested to constitute one of the functions of sleep [Benington, J. H. & Heller H. C. (1995) Prog. Neurobiol., 45, 347]. We have tested the hypothesis that the level of expression of e ...

2002

Elucidation of the role of fructose 2,6-bisphosphate in the regulation of glucose fluxes in mice using in vivo (13)C NMR measurements of hepatic carbohydrate metabolism

Rolf Gruetter

Fructose 2,6-bisphosphate (Fru-2,6-P2) plays an important role in the regulation of major carbohydrate fluxes as both allosteric activator and inhibitor of target enzymes. To examine the role of Fru-2,6-P2 in the regulation of hepatic carbohydrate metaboli ...

2002

A2B receptor activation promotes glycogen synthesis in astrocytes through modulation of gene expression

Pierre Magistretti, Igor Allaman, Sylvain Eric Lengacher, Luc Pellerin

Adenosine has been proposed as a key factor regulating the metabolic balance between energy supply and demand in the central nervous system. Because astrocytes represent an important cellular element in the control of brain energy metabolism, we investigat ...

2002

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