Publications associées à Série génératrice

Enriching the Computational Toolbox for Organocatalysis

Organocatalysis has evolved significantly over the last decades, becoming a pillar of synthetic chemistry, but traditional theoretical approaches based on quantum mechanical computations to investigate reaction mechanisms and provide rationalizations of ca ...

EPFL2023

A DONALDSON-THOMAS CREPANT RESOLUTION CONJECTURE ON CALABI-YAU 4-FOLDS

Sergej Monavari

Let G be a finite subgroup of SU(4) such that its elements have age at most one. In the first part of this paper, we define K-theoretic stable pair invariants on a crepant resolution of the affine quotient C4/G, and conjecture a closed formula for their ge ...

Amer Mathematical Soc2023

Dated: Guidelines for Creating Synthetic Datasets for Engineering Design Applications

Jürg Alexander Schiffmann, Cyril Picard, Faez Ahmed

Exploiting the recent advancements in artificial intelligence, showcased by ChatGPT and DALL-E, in real-world applications necessitates vast, domain-specific, and publicly accessible datasets. Unfortunately, the scarcity of such datasets poses a significan ...

Amer Soc Mechanical Engineers2023

Generative power of a protein language model trained on multiple sequence alignments

Anne-Florence Raphaëlle Bitbol, Umberto Lupo, Damiano Sgarbossa

Computational models starting from large ensembles of evolutionarily related protein sequences capture a representation of protein families and learn constraints associated to protein structure and function. They thus open the possibility for generating no ...

eLIFE SCIENCES PUBL LTD2023

Memory of Motion for Initializing Optimization in Robotics

Teguh Santoso Lembono

Many robotics problems are formulated as optimization problems. However, most optimization solvers in robotics are locally optimal and the performance depends a lot on the initial guess. For challenging problems, the solver will often get stuck at poor loc ...

EPFL2022

Synthesis and direct assay of large macrocycle diversities by combinatorial late-stage modification at picomole scale

Gerardo Turcatti, Christian Heinis, Julien Bortoli Chapalay, Jonathan Patrice Vesin, Alessandro Angelini, Manuel Leonardo Merz, Sevan Mleh Habeshian, Mischa Schüttel, Ganesh Kumar Mothukuri, Gontran Sangouard

Macrocycles have excellent potential as therapeutics due to their ability to bind challenging targets. However, generating macrocycles against new targets is hindered by a lack of large macrocycle libraries for high-throughput screening. To overcome this, ...

Nature Research2022

Scattering Map for the Vlasov–Poisson System

Klaus Martin Widmayer

We construct (modified) scattering operators for the Vlasov–Poisson system in three dimensions, mapping small asymptotic dynamics as t→−∞ to asymptotic dynamics as t→+∞. The main novelty is the construction of modified wave operators, but we also obtain a ...

2023

Enantioselective Total Synthesis of (+)-Nordasycarpidone, (+)-Dasycarpidone, and (+)-Uleine

Qian Wang, Jieping Zhu, Cédric Fung, Bastien Delayre

The structure of uleine type alkaloids is characterized by the presence of a bridged tetracyclic hexahydro-1H-1,5-methanoazocino[4,3-b]indole ring system 1. Various strategies have been developed to access this polycyclic structural motif. We report herein ...

2021

The fourth moment of individual Dirichlet L-functions on the critical line

Berke Topacogullari

We prove an asymptotic formula for the second moment of a product of two Dirichlet L-functions on the critical line, which has a power saving in the error term and which is uniform with respect to the involved Dirichlet characters. As special cases we give ...

2021

TV-based reconstruction of periodic functions

Matthieu Martin Jean-André Simeoni, Julien René Pierre Fageot

We introduce a general framework for the reconstruction of periodic multivariate functions from finitely many and possibly noisy linear measurements. The reconstruction task is formulated as a penalized convex optimization problem, taking the form of a sum ...

IOP PUBLISHING LTD2020