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Publications associées (89)

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Non-invasive spinal cord electrical stimulation for arm and hand function in chronic tetraplegia: a safety and efficacy trial

Grégoire Courtine, Jordan Squair, Markus Maximilian Rieger

Cervical spinal cord injury (SCI) leads to permanent impairment of arm and hand functions. Here we conducted a prospective, single-arm, multicenter, open-label, non-significant risk trial that evaluated the safety and efficacy of ARCEX Therapy to improve a ...

Nature Portfolio2024

Enriching the Computational Toolbox for Organocatalysis

Simone Gallarati

Organocatalysis has evolved significantly over the last decades, becoming a pillar of synthetic chemistry, but traditional theoretical approaches based on quantum mechanical computations to investigate reaction mechanisms and provide rationalizations of ca ...

EPFL2023

Let G be a finite subgroup of SU(4) such that its elements have age at most one. In the first part of this paper, we define K-theoretic stable pair invariants on a crepant resolution of the affine quotient C4/G, and conjecture a closed formula for their ge ...

Providence2023

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Exploiting the recent advancements in artificial intelligence, showcased by ChatGPT and DALL-E, in real-world applications necessitates vast, domain-specific, and publicly accessible datasets. Unfortunately, the scarcity of such datasets poses a significan ...

Amer Soc Mechanical Engineers2023

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Computational models starting from large ensembles of evolutionarily related protein sequences capture a representation of protein families and learn constraints associated to protein structure and function. They thus open the possibility for generating no ...

eLIFE SCIENCES PUBL LTD2023

The objective of this article is to propose a new composite index (CI) that helps to determine the most effective location of servers in an Emergency Care System (ECS), using Benefit of the Doubt (BoD)/Data Envelopment Analysis (DEA) and the Hypercube queu ...

London2023

Synthesis and direct assay of large macrocycle diversities by combinatorial late-stage modification at picomole scale

Christian Heinis, Gerardo Turcatti, Julien Bortoli Chapalay, Alessandro Angelini, Manuel Leonardo Merz, Sevan Mleh Habeshian, Jonathan Patrice Vesin, Mischa Schüttel, Ganesh Kumar Mothukuri, Gontran Sangouard, Cristina Diaz Perlas, Zsolt Bognár

Macrocycles have excellent potential as therapeutics due to their ability to bind challenging targets. However, generating macrocycles against new targets is hindered by a lack of large macrocycle libraries for high-throughput screening. To overcome this, ...

2022

In this article, we prove that double quasi-Poisson algebras, which are noncommutative analogues of quasi-Poisson manifolds, naturally give rise to pre-Calabi-Yau algebras. This extends one of the main results in [11], where a correspondence between certai ...

2022

The Canopy Pavilion: A lightweight shading structure using a deployable auxetic linkage membrane

Mark Pauly, Dieter Dietz, Florin Isvoranu, Arthur François Blanc, Tian Chen, Etienne Bouleau

We present the Canopy Pavilion, a lightweight shading structure for a social gathering space. The shading surface is realized as a tensioned auxetic linkage membrane, composed of two double-curved anticlastic layers separated by a compression pole. The mem ...

2022

We construct (modified) scattering operators for the Vlasov–Poisson system in three dimensions, mapping small asymptotic dynamics as t→−∞ to asymptotic dynamics as t→+∞. The main novelty is the construction of modified wave operators, but we also obtain a ...

2021