Concept

Plasma cell dyscrasias

Publications associées (59)

Ceramic hydroxyapatite: a new tool for separation and analysis of IgA monoclonal antibodies

A novel downstream process is reported for preparative scale prodn. of dimeric IgA, a protein with potential pharmaceutical applications. Time-consuming size exclusion chromatog. was replaced by ceramic hydroxyapatite chromatog. (CHT). A clear baseline sep ...

1997

Multiple immune abnormalities in tumor necrosis factor and lymphotoxin-alpha double-deficient mice

Michel Aguet, Michael Müller

To investigate the roles of tumor necrosis factor (TNF) and lymphotoxin (LT)-alpha in the development and function of the immune system, the Tnf and Ltalpha genes were simultaneously inactivated in mice by homologous recombination. These mutant mice are hi ...

1996

Characterization of monoclonal IgA production and activity in hollow-fiber and fluidized-bed reactors

Urs von Stockar, Ian William Marison

An IgA-producing hybridoma cell line has been grown in two hollow-fiber reactors and one fluidized-bed reactor, using a serum-contg. medium and a protein-free medium. Comparisons have been made on the basis of product quantity (total IgA) and quality (acti ...

Elsevier1996

Further evidence for the clonal nature of the idiopathic hypereosinophilic syndrome: complete haematological and cytogenetic remission induced by interferon-alpha in a case with a unique chromosomal abnormality

Hubert van den Bergh

A 49-year-old man with the idiopathic hypereosinophilic syndrome (HES) and a unique chromosomal abnormality 46,XY,t(5;9)(q32;q33) is reported. Complete cytogenetic remission was induced by interferon alpha-2b (IFN-alpha). The beneficial action of IFN-alpha ...

1996

Systematic improvement of a chemically-defined protein-free medium for hybridoma growth and monoclonal antibody production

Urs von Stockar, Ian William Marison

A chemically-defined protein-free medium (FMX-Turbodoma) has been improved for the production of monoclonal IgA antibodies by hybridoma cells, using a systematic method. Cell growth rate, IgA production, activity and molecular weight pattern have been used ...

1996

Biomaterials in tissue engineering

Jeffrey Alan Hubbell

Biomaterials play a pivotal role in field of tissue engineering. Biomimetic synthetic polymers have been created to elicit specific cellular functions and to direct cell-cell interactions both in implants that are initially cell-free, which may serve as ma ...

1995

Production of immunoglobulin A in different reactor configurations

Urs von Stockar, Ian William Marison

A murine hybridoma line (Zac3), secreting an IgA monoclonal antibody, was cultivated in different systems: a BALB/c mouse, a T-flask, a stirred-tank bioreactor and a hollow fiber reactor. These systems were characterized in terms of cell metab. and perform ...

1995

Expansion of gamma delta+ T cells in BALB/c mice infected with Leishmania major is dependent upon Th2-type CD4+ T cells

Michel Aguet, Friedrich Beermann, Anne Wilson

T cells belong to either the alpha beta+ or gamma delta+ lineage as defined by their antigen receptor. Although both T-cell subsets have been shown to be involved in the immune response to the parasite Leishmania major, very little is known about possible ...

1995

Polyclonal rearrangements of the T-cell receptor beta-chain in fatal angioimmunoblastic lymphadenopathy

Lukas Kühn

Genomic rearrangement of germline T-cell antigen receptor (TcR) and immunoglobulin (Ig) genes was studied by Southern blot analysis in seven patients with angioimmunoblastic lymphadenopathy (AILD). In three cases clinically suspected of transformation into ...

1989

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